Functional and molecular profiling of platelet hyperactivity in diabetes - uncovering dysregulated and targetable pathways for potential treatments

糖尿病血小板过度活跃的功能和分子分析——揭示潜在治疗的失调和靶向途径

• 批准号: nhmrc : 1146025
• 金额: $ 21.82万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-molecular-profiling-potential-treatments/1320580
• 关键词: Functional; molecular; profiling; platelet; hyperactivity

The major cause of death in diabetes is cardiovascular disease. Diabetic patients are more likely to have hardening of their arteries, and an increased propensity to form pathological blood clots. I propose to characterise platelet “hyperactivity” in diabetes both at a functional and molecular level. This unique approach aims to identify the underlying mechanism of platelet hyperactivity which may be targeted in future treatments.

糖尿病的主要死因是心血管疾病。糖尿病患者更有可能有动脉硬化，并增加形成病理性血凝块的倾向。我建议在功能和分子水平上研究糖尿病中血小板的“过度活跃”。这种独特的方法旨在确定血小板过度活跃的潜在机制，这可能是未来治疗的目标。