Differential expression of collagen by TGF-b1 & b3

描述(申请人提供)：成人伤口过度收缩和瘢痕形成不足的特点是胶原沉积导致许多病理情况，如肠粘连和压疮，这些疾病几乎没有治疗选择。相比之下，胎儿创面愈合时没有疤痕，III型胶原与1A1型胶原沉积的比例高于成人创面。转化生长因子-β(TGF-β)被认为是伤口愈合的重要介质，其异构体可能在胎儿无瘢痕创面向成人瘢痕形成创面的过渡过程中发挥作用。本研究旨在探讨转化生长因子-β1和转化生长因子-β3在体外模型中是否利用相同的细胞表面受体通过不同的细胞信号通路不同地调节前胶原1a1和前胶原III型基因的表达，从而探讨转化生长因子-β与创面愈合的关系。

DESCRIPTION (provided by applicant): Excess wound contraction and inadequate scar formation in the adult are characterized by collagen deposition resulting in numerous pathologic conditions such as intestinal adhesions and pressure ulcers, for which there are few therapeutic options. In contrast, fetal wounds heal with scarlessly and with a higher ratio of collagen type III to type 1a1 deposition than in adult wounds. Transforming growth factor beta (TGF-b) has been implicated to be an important mediator of wound healing and the TGF-b isoforms may have a role in both the transition from the fetal scarless wound to the adult scar-forming wound. This study aims at exploring the relationship between TGF-b and wound healing by determining if TGF-b1 and -b3 differentially regulate procollagen 1a1 and procollagen III gene expression in an in vitro model by using the same cell- surface receptor yet through different cell signaling pathways.