Aging and Physical Functioning in HIV

艾滋病毒的衰老和身体机能

基本信息

  • 批准号:
    7230643
  • 负责人:
  • 金额:
    $ 13.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-30 至 2010-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The candidate is a promising young investigator with board certifications in Internal Medicine and Infectious Disease, and a Masters of Science degree in Clinical Investigation, who has made a substantial commitment to an academic career in patient-oriented research in aging and HIV. The career plan and research proposal are consistent with her long-term goal to become an independent clinical investigator, and leader in academic geriatric medicine and HIV. Older individuals represent an increasingly larger proportion of adults living with HIV infection in the United States. Reduced aerobic capacity, mitochondrial oxidative dysfunction and loss of lean muscle mass are problems that affect both HIV-infected and non-infected older adults. However sarcopenia and oxidative dysfunction may be more pronounced in the presence of HIV, with the deficits further compounded by the metabolic effects of antiretroviral therapy. Understanding the underlying mechanisms of limited functional performance in older HIV adults will allow us to design effective prevention and treatment strategies that will improve and preserve function in this rapidly growing older patient population. The objective of this proposal is to investigate the mechanisms by which aging affects physical functioning and aerobic capacity in HIV adults (AIM 1), and to determine if aerobic exercise training improves functional and cardiovascular performance in older HIV adults (AIM 2). Hypothesis #1. Reduced physical functioning with aging will be affected by baseline immune status in HIV adults, and will be similarly affected by medical comorbid conditions in HIV-infected vs. negative adults. Hypothesis #2. Skeletal muscle oxidative dysfunction is a central factor associated with reduced aerobic capacity and functional limitations in older HIV adults. Hypothesis #3. Aerobic exercise training will improve muscle oxidative dysfunction, and the associated functional limitations and reduced aerobic capacity in older HIV subjects compared to sedentary older HIV controls; however, improvements may be limited by the extent of sarcopenia and HIV-related myopathy. The proposed research will lay the foundation for subsequent studies that will investigate the optimal exercise-based rehabilitation strategies and the mechanisms by which they improve physical functioning in older HIV adults, and methods for their translation into community sites.
DESCRIPTION (provided by applicant): The candidate is a promising young investigator with board certifications in Internal Medicine and Infectious Disease, and a Masters of Science degree in Clinical Investigation, who has made a substantial commitment to an academic career in patient-oriented research in aging and HIV. The career plan and research proposal are consistent with her long-term goal to become an independent clinical investigator, and leader in academic geriatric medicine and HIV. Older individuals represent an increasingly larger proportion of adults living with HIV infection in the United States. Reduced aerobic capacity, mitochondrial oxidative dysfunction and loss of lean muscle mass are problems that affect both HIV-infected and non-infected older adults. However sarcopenia and oxidative dysfunction may be more pronounced in the presence of HIV, with the deficits further compounded by the metabolic effects of antiretroviral therapy. Understanding the underlying mechanisms of limited functional performance in older HIV adults will allow us to design effective prevention and treatment strategies that will improve and preserve function in this rapidly growing older patient population. The objective of this proposal is to investigate the mechanisms by which aging affects physical functioning and aerobic capacity in HIV adults (AIM 1), and to determine if aerobic exercise training improves functional and cardiovascular performance in older HIV adults (AIM 2). Hypothesis #1. Reduced physical functioning with aging will be affected by baseline immune status in HIV adults, and will be similarly affected by medical comorbid conditions in HIV-infected vs. negative adults. Hypothesis #2. Skeletal muscle oxidative dysfunction is a central factor associated with reduced aerobic capacity and functional limitations in older HIV adults. Hypothesis #3. Aerobic exercise training will improve muscle oxidative dysfunction, and the associated functional limitations and reduced aerobic capacity in older HIV subjects compared to sedentary older HIV controls; however, improvements may be limited by the extent of sarcopenia and HIV-related myopathy. The proposed research will lay the foundation for subsequent studies that will investigate the optimal exercise-based rehabilitation strategies and the mechanisms by which they improve physical functioning in older HIV adults, and methods for their translation into community sites.

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KRISANN K OURSLER其他文献

KRISANN K OURSLER的其他文献

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{{ truncateString('KRISANN K OURSLER', 18)}}的其他基金

Home-Based Exercise Tele-Rehabilitation in High-Risk Veterans: Impact of COVID-19 Exposure and Socioeconomic Factors
高风险退伍军人的家庭远程运动康复:COVID-19 暴露和社会经济因素的影响
  • 批准号:
    10538686
  • 财政年份:
    2022
  • 资助金额:
    $ 13.47万
  • 项目类别:
Home-Based Exercise Tele-Rehabilitation in High-Risk Veterans: Impact of COVID-19 Exposure and Socioeconomic Factors
高风险退伍军人的家庭远程运动康复:接触 COVID-19 和社会经济因素的影响
  • 批准号:
    10731368
  • 财政年份:
    2022
  • 资助金额:
    $ 13.47万
  • 项目类别:
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
  • 批准号:
    8485305
  • 财政年份:
    2014
  • 资助金额:
    $ 13.47万
  • 项目类别:
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
  • 批准号:
    9924244
  • 财政年份:
    2014
  • 资助金额:
    $ 13.47万
  • 项目类别:
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
  • 批准号:
    8990397
  • 财政年份:
    2014
  • 资助金额:
    $ 13.47万
  • 项目类别:
Aging and Physical Functioning in HIV
艾滋病毒的衰老和身体机能
  • 批准号:
    7913496
  • 财政年份:
    2009
  • 资助金额:
    $ 13.47万
  • 项目类别:
FITNESS AND LONGEVITY IN EXERCISE: FLEX
运动中的健身和长寿:FLEX
  • 批准号:
    7951178
  • 财政年份:
    2009
  • 资助金额:
    $ 13.47万
  • 项目类别:
FITNESS AND LONGEVITY IN EXERCISE: FLEX
运动中的健身和长寿:FLEX
  • 批准号:
    7718097
  • 财政年份:
    2008
  • 资助金额:
    $ 13.47万
  • 项目类别:
GERIATRIC EXERCISE TRAINING FOR FITNESS (GETFIT)
老年健身运动训练 (GETFIT)
  • 批准号:
    7608132
  • 财政年份:
    2007
  • 资助金额:
    $ 13.47万
  • 项目类别:
Aging and Physical Functioning in HIV
艾滋病毒的衰老和身体机能
  • 批准号:
    7643217
  • 财政年份:
    2006
  • 资助金额:
    $ 13.47万
  • 项目类别:

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    5258762
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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