Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
基本信息
- 批准号:8990397
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-04-01 至 2018-03-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAerobicAerobic ExerciseAgeAge-YearsAgingAmericanAttenuatedBiological MarkersBody CompositionCD4 Lymphocyte CountCardiacCardiovascular DiseasesCardiovascular systemCessation of lifeChronicChronically IllComplexDataDeteriorationDiastolic heart failureEFRACElderlyExerciseFibrosisFoundationsFunctional disorderFutureGoalsHIVHealthHealth PersonnelHeart RateHeart failureImmuneImpairmentIndividualInfectionInflammationInflammatoryLifeLiftingMediatingMetabolicMuscleMuscle WeaknessMyocardiumObesityOrganOutcomePatientsPerformancePeripheralPhysical FunctionPhysically HandicappedPopulationPrognostic FactorRandomizedRecommendationRehabilitation ResearchRehabilitation therapyResearchResistanceRiskRisk FactorsSkeletal MuscleSports MedicineTestingTrainingTranslational ResearchUnited StatesVariantVeteransage effectage relatedbasecollegecoronary fibrosiscytokinedeconditioningfunctional declineimprovedinsightmiddle agemortalitymuscle formmuscle strengthnovelpatient populationpreventprogramspublic health relevancerehabilitation strategysarcopeniasedentarystrength trainingtreatment as usualweek trial
项目摘要
DESCRIPTION (provided by applicant):
In older adults, chronic inflammation is an independent risk factor for poor physical function, muscle weakness, cardiovascular disease, and mortality. Similarly, increased levels of biomarkers of inflammation in HIV-infected adults independently predict cardiovascular disease and death, regardless of immune status. HIV-infected adults have increased risk for poor aerobic capacity, muscle weakness and sarcopenia, all of which may be accelerated by chronic inflammation. Yet, the impact of chronic inflammation on these outcomes and the effect of exercise training is not well understood. In HIV negative adults with diastolic dysfunction, biomarkers of inflammation and cardiac fibrosis predict cardiac function and mortality. In elderly HIV negative adults with diastolic dysfunction, aerobic exercise training increases aerobic capacity 16%. HIV-infected adults have a 4- fold increased risk of diastolic dysfunction. Our preliminary data indicates that diastolic dysfunction is associated with poor aerobic capacity in asymptomatic HIV-infected veterans. Exercise rehabilitation studies in younger HIV-infected adults, based on American College of Sports Medicine (ACSM) recommendations, show improvements in aerobic capacity, muscle weakness and sarcopenia but limited data are available in older HIV-infected adults. Our preliminary data shows that high-intensity aerobic exercise training in older HIV- infected adults is well tolerated and increases aerobic capacity by
17%. The effects on diastolic function, and correlates of systemic inflammation and cardiac fibrosis, are unknown in this population. The objective of this study is to determine the effect o exercise training on the central (cardiovascular) and peripheral (muscular) impairments underlying poor physical function by comparing older HIV-infected veterans randomized to combined aerobic and resistance exercise training versus usual care. Our hypothesis is that a progressive aerobic and resistance rehabilitation program will increase aerobic capacity and muscle strength, which will be mediated by improved diastolic function, increased muscle mass, and decreased systemic inflammation. To test this hypothesis, we will conduct a randomized 16-week trial of progressive aerobic and resistance training versus usual care control in 60 sedentary older (50+ years) HIV- infected veterans. We will determine the effects of exercise training on aerobic capacity and diastolic function, and their relationship to changes in biomarkers of systemic inflammation and cardiac fibrosis (AIM 1). We will also determine the effect of exercise training on strength and muscle mass, and their relationship to changes in biomarkers of systemic inflammation (AIM 2). The VA is the largest health care provider for HIV-infected individuals in the United States with over 25,000 patients, of which 64% are over 50 years of age. Findings from this novel translational research will provide the foundation for future mechanistic research to investigate organ-specific effects of exercise training, including cardiac remodeling and fibrosis, and skeletal muscle expression of inflammatory cytokines. Collectively, the proposed research will advance our goal to develop effective rehabilitation strategies that improve the health and functional independence of HIV-infected veterans.
PUBLIC HEALTH RELEVANCE:
Research is needed to determine safe and effective exercise rehabilitation programs to prevent and improve physical disability in older adults living with HIV. This problem is of great importance to the VA. The majority of the 25 thousand HIV-infected veterans are over 50 years of age (64%). The combined effect of aging and inflammation increase the risk for physical disability in older HIV-infected veterans. This translational exercise training trial will examine he cardiac and skeletal muscle effects of combined aerobic exercise and resistance training to attenuate the functional declines of aging with HIV by reducing the deleterious consequences of chronic inflammation. Findings will guide future rehabilitation research on cardiac remodeling and inflammation of skeletal muscle. The proposed research will advance the goal to develop effective rehabilitation strategies that improve the health of older HIV-infected veterans.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KRISANN K OURSLER其他文献
KRISANN K OURSLER的其他文献
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{{ truncateString('KRISANN K OURSLER', 18)}}的其他基金
Home-Based Exercise Tele-Rehabilitation in High-Risk Veterans: Impact of COVID-19 Exposure and Socioeconomic Factors
高风险退伍军人的家庭远程运动康复:COVID-19 暴露和社会经济因素的影响
- 批准号:
10538686 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Home-Based Exercise Tele-Rehabilitation in High-Risk Veterans: Impact of COVID-19 Exposure and Socioeconomic Factors
高风险退伍军人的家庭远程运动康复:接触 COVID-19 和社会经济因素的影响
- 批准号:
10731368 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
- 批准号:
8485305 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Effect of Exercise Training on Inflammation and Function in HIV Infected Veterans
运动训练对感染艾滋病毒的退伍军人炎症和功能的影响
- 批准号:
9924244 - 财政年份:2014
- 资助金额:
-- - 项目类别:
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