Bone Accrual and Hormones in Response to Lactation

哺乳期的骨质增生和激素

• 批准号: 7106428
• 负责人: SUE A BROWN
• 金额: $ 12.62万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106428
• 关键词: 1,25 dihydroxycholecalciferol; bone density; bone regeneration; breast feeding; clinical research; estradiol; estrogens; female; hormone regulation /control mechanism; human subject; insulinlike growth factor; lactation; longitudinal human study; menopause; osteogenesis; parathyroid hormone related protein; parathyroid hormones; pathologic bone resorption; patient oriented research; photon absorptiometry; postmenopause; weaning; women' s health

DESCRIPTION (provided by applicant): This career development grant will prepare the candidate to pursue her goal of becoming an independently funded academician devoted to investigating pre- menopausal determinants of bone health and the preventive efforts that will maintain healthy bone remodeling in young women. The novel research proposed in this application benefits from mentoring by a strong, multidisciplinary team of senior investigators and uses lactation as a physiological model of bone loss during estrogen deficiency and subsequent recovery of bone density after weaning. By studying lactation, there is the opportunity to identify optimal conditions for bone mass remodeling and formation. The overall hypotheses of this proposal are that 1) the skeletal response to lactation is mediated through the elaboration of one or more anabolic hormones in conjunction with the return of adequate estradiol production; and 2) these events lead to both quantitative (BMD) and qualitative (bone geometry) changes in the skeleton that may confer a structural advantage for women later in life. In aim 1, a prospective cohort study will be conducted in postpartum women to assess hormonal determinants of bone density losses and recovery and an assessment of bone structural parameters usingdual-energy x-ray absorptiometry (DXA). Aim 1 will utilize a large, well-established clinical cohort enrolling pregnant women at UNC-CH (PIN Study). In aim 2, the association of lactation duration and bone mineral density later in life will be examined using a cohort originally assembled in 1978 (NIEHS - Timing of Menopause Study). This cohort has the advantage of having lactation history well documented in the past. In addition to the mentored research, the candidate will undertake formal advanced training in epidemiology, biostatistics and outcomes research that will allow her to solidify her foundation in clinical research and epidemiological principles. The application benefits from the robust, research-intensive environment and resources provided by the Division of Endocrinology, the General Clinical Research Center, and the School of Public Health at UNC as well as assured access to the clinical populations of the two large, well-established cohorts. The combination of protected time for mentored research and didactics are ideal and will allow her to develop the experience, skills and preliminary data to develop as an independent clinician-scientist.

描述（由申请人提供）： 这项职业发展补助金将使候选人做好准备，以追求她的目标，成为一名独立资助的院士，致力于调查绝经前骨健康的决定因素和预防措施，将保持健康的骨重塑在年轻女性。本申请中提出的新研究受益于由高级研究人员组成的强大的多学科团队的指导，并使用哺乳作为雌激素缺乏期间骨丢失的生理模型以及断奶后骨密度的后续恢复。通过研究哺乳，有机会确定骨量重建和形成的最佳条件。这一建议的总体假设是：1）骨骼对哺乳的反应是通过一种或多种合成代谢激素的分泌以及足够的雌二醇产生的恢复来介导的; 2）这些事件导致骨骼的定量（BMD）和定性（骨几何学）变化，这可能为女性以后的生活带来结构优势。在目标1中，将在产后妇女中进行一项前瞻性队列研究，以评估骨密度损失和恢复的激素决定因素，并使用双能X线吸收测定法（DXA）评估骨结构参数。目标1将利用一个大型、完善的临床队列，在UNC-CH招募孕妇（PIN研究）。在目标2中，将使用最初于1978年组装的队列（NIEHS -绝经时间研究）来检查哺乳期持续时间与生命后期骨矿物质密度的关联。该队列的优势在于过去有良好的哺乳史记录。 除了指导研究，候选人将进行流行病学，生物统计学和成果研究的正式高级培训，这将使她能够巩固她在临床研究和流行病学原则的基础。该应用程序受益于内分泌科，一般临床研究中心和公共卫生学院提供的强大的研究密集型环境和资源，以及确保获得两个大型，完善的队列的临床人群。指导研究和教学法的保护时间的结合是理想的，将使她能够发展经验，技能和初步数据，以发展成为一名独立的临床科学家。