HORMONAL DETERMINANTS OF BONE TURNOVER DURING LACTATION IN POSTPARTUM WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案使用哺乳作为雌激素缺乏期间骨丢失的生理模型，并在断奶后随后恢复骨密度。通过对哺乳期的研究，有机会确定骨量重塑和形成的最佳条件。这一建议的总体假设是：1)骨骼对哺乳期的反应是通过一种或多种合成代谢激素(IGF-1)的形成以及雌激素的恢复来调节的；以及2)这些事件导致骨骼的数量(BMD)和质量(骨骼几何)变化，这可能为以后的女性提供结构优势。这项前瞻性队列研究将在产后妇女中进行，以评估骨密度丢失和恢复的激素决定因素，并使用DXA和pQCT和/或MRI评估骨结构参数。 使用DXA和pQCT恢复和评估骨结构参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol uses lactation as a physiological model of bone loss during estrogen deficiency and subsequent recovery of bone density after weaning. By studying lactation, there is the opportunity to identify optimal conditions for bone mass remodeling and formation. The overall hypotheses of this proposal are that 1) the skeletal response to lactation is mediated through the elaboration of one or more anabolic hormones (IGF-1) in conjunction with the return of adequate estradiol production; and 2) these events lead to both quantitative (BMD) and qualitative (bone geometry) changes in the skeleton that may confer a structural advantage for women later in life. This prospective cohort study will be conducted in postpartum women to assess hormonal determinants of bone density losses and recovery and an assessment of bone structural parameters using DXA and pQCT and/or MRI. recovery and an assessment of bone structural parameters using DXA and pQCT.