HORMONAL DETERMINANTS OF BONE TURNOVER DURING LACTATION IN POSTPARTUM WOMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 该方案使用哺乳作为雌激素缺乏期间骨丢失和随后断奶后骨密度恢复的生理模型。通过研究哺乳，有机会确定骨量重建和形成的最佳条件。该建议的总体假设是：1）骨骼对哺乳的反应是通过一种或多种合成代谢激素（IGF-1）的产生以及足够的雌二醇产生的恢复来介导的; 2）这些事件导致骨骼的定量（BMD）和定性（骨几何形状）变化，这可能为女性以后的生活带来结构优势。 这项前瞻性队列研究将在产后妇女中进行，以评估骨密度损失和恢复的激素决定因素，并使用DXA和pQCT和/或MRI评估骨结构参数。 恢复和使用DXA和pQCT评估骨结构参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol uses lactation as a physiological model of bone loss during estrogen deficiency and subsequent recovery of bone density after weaning. By studying lactation, there is the opportunity to identify optimal conditions for bone mass remodeling and formation. The overall hypotheses of this proposal are that 1) the skeletal response to lactation is mediated through the elaboration of one or more anabolic hormones (IGF-1) in conjunction with the return of adequate estradiol production; and 2) these events lead to both quantitative (BMD) and qualitative (bone geometry) changes in the skeleton that may confer a structural advantage for women later in life. This prospective cohort study will be conducted in postpartum women to assess hormonal determinants of bone density losses and recovery and an assessment of bone structural parameters using DXA and pQCT and/or MRI. recovery and an assessment of bone structural parameters using DXA and pQCT.