Attention and Memory Influences on Navigation in AD

注意力和记忆力对 AD 导航的影响

• 批准号: 7014030
• 负责人: MARK MAPSTONE
• 金额: $ 11.56万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7014030
• 关键词: Alzheimer' s disease; aging; attention; behavioral /social science research tag; cholinesterase inhibitors; clinical research; cues; dementia; human subject; memory; motion perception; neuropharmacology; neuropsychology; neuroregulation; patient oriented research; psychophysics; space perception; visual fields

DESCRIPTION (provided by applicant): Spatial disorientation is a primary manifestation of Alzheimer's disease (AD) greatly impacting functional independence. While the amnesic features of AD are well described, relatively little is known about the deficits underlying spatial disorientation. Spatial disorientation in AD has been attributed to pervasive memory dysfunction, but it can present without evident memory deficits. Alternatively, spatial disorientation in AD may reflect a reduction in the size of the spatial window of attention; the area of the visual field that is simultaneously accessed by cognition. Narrowing the attentional window might limit access to orientation cues in global patterns of optic flow and force reliance on less informative object motion cues. I propose to immerse myself in the study of spatial disorientation in Alzheimer's disease for the next five years. Through formal instruction, hands-on laboratory experience, and completion of the research plan described within. l will further develop skills in patient-oriented research leading to competence as an independent investigator. The strength of my approach is a core group of mentors selected for their expertise in addressing the proposed research topic and for their commitment to developing young investigators. Charles Dully, MD, PhD (visual psychophysics), Roger Kurlan, MD (neurological disease clinical trials), and Suzanne Corkin, PhD (behavioral studies of memory) have agreed to share their specific expertise and serve as mentors in my transition to independent investigator. The specific aims of the proposed research are 1 ) To quantify the size of the window of attention in patients with AD and investigate its effect on the use global motion (optic flow) and local motion (object) cues for determining heading, 2) To determine the contributions of spatial attention and memory systems for path integration, and 3) To explore the role of the cholinergic system as a neuro-modulator for spatial attention and global motion processing using pharmacological challenge. This funding will provide for my further development in behavioral studies of spatial attention in aging and AD and commence my programmatic approach to the study of brain-behavior relationships.

描述(申请人提供)：空间定向障碍是阿尔茨海默病(AD)的主要表现，极大地影响功能独立。虽然阿尔茨海默病的健忘特征被很好地描述了，但对空间定向障碍背后的缺陷知之甚少。阿尔茨海默病的空间定向障碍被归因于普遍的记忆功能障碍，但它可以在没有明显记忆缺陷的情况下出现。或者，阿尔茨海默病的空间定向障碍可能反映了注意的空间窗口大小的减小，即同时由认知进入的视野区域。缩小注意窗口可能会限制对全局光流模式中的方位线索的访问，并迫使人们依赖信息量较少的物体运动线索。 我建议在接下来的五年里全身心地投入阿尔茨海默病空间定向障碍的研究。通过正式的指导，动手的实验室经验，以及完成中所述的研究计划。L将进一步发展以患者为中心的研究技能，从而具备独立调查人员的能力。我的方法的优势是选择了一个核心导师小组，因为他们在解决拟议的研究主题方面具有专门知识，并致力于培养年轻的研究人员。查尔斯·杜利，医学博士，视觉心理物理学博士，罗杰·库伦，医学博士(神经疾病临床试验)，苏珊娜·科金(记忆行为研究)，已经同意分享他们的专业知识，并在我向独立调查员过渡的过程中担任导师。 这项研究的具体目的是：1)量化AD患者注意窗口的大小，并研究其对使用全局运动(光流)和局部运动(物体)线索确定航向的影响；2)确定空间注意和记忆系统对路径整合的贡献；3)利用药物挑战探索胆碱能系统作为空间注意和全局运动处理的神经调节器的作用。 这笔资金将为我在衰老和阿尔茨海默病中空间注意力的行为研究方面提供进一步的发展，并开始我的脑-行为关系研究的程序性方法。