Attention and Memory Influences on Navigation in Alzheimer's Disease

描述（申请人提供）：空间定向障碍是阿尔茨海默病（AD）的主要表现，严重影响功能独立性。虽然阿尔茨海默氏症的失忆特征被很好地描述，但相对而言，人们对空间定向障碍的潜在缺陷知之甚少。阿尔茨海默氏症的空间定向障碍被认为是普遍的记忆功能障碍，但它可能没有明显的记忆缺陷。或者，AD的空间定向障碍可能反映了空间注意窗口大小的减小；视野区：同时被认知所进入的视野区域缩小注意窗口可能会限制对全局光流模式中的方向线索的获取，并迫使对信息较少的物体运动线索的依赖。

DESCRIPTION (provided by applicant): Spatial disorientation is a primary manifestation of Alzheimer's disease (AD) greatly impacting functional independence. While the amnesic features of AD are well described, relatively little is known about the deficits underlying spatial disorientation. Spatial disorientation in AD has been attributed to pervasive memory dysfunction, but it can present without evident memory deficits. Alternatively, spatial disorientation in AD may reflect a reduction in the size of the spatial window of attention; the area of the visual field that is simultaneously accessed by cognition. Narrowing the attentional window might limit access to orientation cues in global patterns of optic flow and force reliance on less informative object motion cues. I propose to immerse myself in the study of spatial disorientation in Alzheimer's disease for the next five years. Through formal instruction, hands-on laboratory experience, and completion of the research plan described within. l will further develop skills in patient-oriented research leading to competence as an independent investigator. The strength of my approach is a core group of mentors selected for their expertise in addressing the proposed research topic and for their commitment to developing young investigators. Charles Dully, MD, PhD (visual psychophysics), Roger Kurlan, MD (neurological disease clinical trials), and Suzanne Corkin, PhD (behavioral studies of memory) have agreed to share their specific expertise and serve as mentors in my transition to independent investigator. The specific aims of the proposed research are 1 ) To quantify the size of the window of attention in patients with AD and investigate its effect on the use global motion (optic flow) and local motion (object) cues for determining heading, 2) To determine the contributions of spatial attention and memory systems for path integration, and 3) To explore the role of the cholinergic system as a neuro-modulator for spatial attention and global motion processing using pharmacological challenge. This funding will provide for my further development in behavioral studies of spatial attention in aging and AD and commence my programmatic approach to the study of brain-behavior relationships.