Attention and Memory Influences on Navigation in Alzheimer's Disease

注意力和记忆力对阿尔茨海默病导航的影响

• 批准号: 7188559
• 负责人: MARK MAPSTONE
• 金额: $ 11.83万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188559
• 关键词: Accounting; Address; Affect; Aging; Alzheimer' s Disease; Area; Attention; Behavioral; Cerebral cortex; Cholinergic Agents; Cholinergic Agonists; Cholinergic Antagonists; Clinical Trials; Cognition; Cognitive; Competence; Cues; Development; Disorientation; Doctor of Philosophy; Dorsal; Elderly; Environment; Equipment; Event; Experimental Designs; Foundations; Functional disorder; Funding; Goals; Hand; Head; Impairment; Instruction; Laboratories; Link; Measures; Memory; Memory impairment; Mentors; Motion; Motion Perception; Movement; Patients; Pattern; Positioning Attribute; Procedures; Process; Range; Relative (related person); Reliance; Research; Research Personnel; Role; Seminal; Series; Simulate; Space Perception; Stream; Syndrome; System; Testing; Visual; Visual Fields; Visual Motion; Visual Psychophysics; Visuospatial; Work; attentional modulation; base; brain behavior; cholinergic; experience; human subject; memory process; nervous system disorder; nonhuman primate; object motion; optic flow; patient oriented research; programs; research study; size; skills; success; visual process; visual processing

DESCRIPTION (provided by applicant): Spatial disorientation is a primary manifestation of Alzheimer's disease (AD) greatly impacting functional independence. While the amnesic features of AD are well described, relatively little is known about the deficits underlying spatial disorientation. Spatial disorientation in AD has been attributed to pervasive memory dysfunction, but it can present without evident memory deficits. Alternatively, spatial disorientation in AD may reflect a reduction in the size of the spatial window of attention; the area of the visual field that is simultaneously accessed by cognition. Narrowing the attentional window might limit access to orientation cues in global patterns of optic flow and force reliance on less informative object motion cues. I propose to immerse myself in the study of spatial disorientation in Alzheimer's disease for the next five years. Through formal instruction, hands-on laboratory experience, and completion of the research plan described within. l will further develop skills in patient-oriented research leading to competence as an independent investigator. The strength of my approach is a core group of mentors selected for their expertise in addressing the proposed research topic and for their commitment to developing young investigators. Charles Dully, MD, PhD (visual psychophysics), Roger Kurlan, MD (neurological disease clinical trials), and Suzanne Corkin, PhD (behavioral studies of memory) have agreed to share their specific expertise and serve as mentors in my transition to independent investigator. The specific aims of the proposed research are 1 ) To quantify the size of the window of attention in patients with AD and investigate its effect on the use global motion (optic flow) and local motion (object) cues for determining heading, 2) To determine the contributions of spatial attention and memory systems for path integration, and 3) To explore the role of the cholinergic system as a neuro-modulator for spatial attention and global motion processing using pharmacological challenge. This funding will provide for my further development in behavioral studies of spatial attention in aging and AD and commence my programmatic approach to the study of brain-behavior relationships.

描述（由申请人提供）：空间定向障碍是阿尔茨海默病（AD）的主要表现，极大地影响功能独立性。虽然AD的遗忘特征被很好地描述，但对空间定向障碍的缺陷知之甚少。 AD患者的空间定向障碍被认为是广泛性记忆功能障碍，但它可以在没有明显记忆缺陷的情况下出现。或者，AD的空间定向障碍可能反映了注意力空间窗口的大小减少;认知同时访问的视野区域。缩小注意窗口可能会限制访问的全球模式的光流和部队的方向线索的依赖信息较少的对象运动线索。 我打算在接下来的五年里把自己沉浸在阿尔茨海默病的空间定向障碍的研究中。通过正式的指导，动手实验室的经验，并完成内所述的研究计划。l将进一步发展以患者为导向的研究技能，从而成为独立研究者。 我的方法的优势是一组核心导师，他们在解决拟议的研究课题方面的专业知识和他们对培养年轻研究人员的承诺。 Charles Dully，MD，PhD（视觉心理物理学），Roger Kurlan，MD（神经疾病临床试验）和Suzanne Corkin，PhD（记忆行为研究）已同意分享他们的专业知识，并在我向独立研究者过渡时担任导师。 本研究的具体目的是：1）量化AD患者注意窗口的大小，并研究其对使用全局运动的影响（光流）和局部运动（物体）线索用于确定航向，2）为了确定空间注意和记忆系统对路径整合的贡献，（3）通过药理学方法探讨胆碱能系统在空间注意和整体运动加工中的作用。 这笔资金将为我在衰老和AD中空间注意力行为研究的进一步发展提供资金，并开始我对大脑行为关系研究的程序化方法。