U.T. SOUTHWESTERN ADULT AIDS CLINICAL TRIALS UNIT

描述(改编自申请者的摘要)： 德克萨斯大学西南医学中心艾滋病临床试验单位 (UTSMC ACTU)将对HIV感染和免疫的免疫发病机制进行研究 接受HAART治疗的患者的重建。专门知识的具体领域 包括成人胸腺在患者免疫重建中的作用 HAART，HIV特异性的CD4和CD8 T细胞反应在对照中的作用 正在接受和没有接受艾滋病毒治疗的患者中艾滋病毒复制的情况 感染，以及免疫激活在艾滋病毒免疫发病机制中的作用。在……里面 此外，UTSMC ACTU的调查人员在以下方面拥有广泛的专业知识 脂营养不良，他们将把它带到蛋白酶的研究中 抑制剂型脂肪营养不良。考虑到在临床和临床上的优势 对于基础科学，他们认为拟议中的UTSMC ACTU将作为一个 AACTG开发新的有效治疗方法的使命的组成部分 通过更好地了解艾滋病毒感染的基本机制 HIV所致疾病的发病机制。UTSMC ACTU的总体目标 将致力于促进亚洲及太平洋区域协调小组的使命。这将涉及到 招募和保留合适的患者参加已开发的临床试验 在咨询委员会的框架内。这些患者将包括所有 临床设施所服务的不同人群。更重要的是， 他们设想成为科学研究议程的积极参与者 委员会，并将对其知识库和未来作出重大贡献 方向。为了完成这一目标，UTSMC的具体目标 ACTU将：(1)为艾滋病毒疾病研究议程作出贡献；(2) 促进艾滋病毒疾病研究议程的复杂化；(3) 对免疫学研究议程作出贡献；以及(4)对其他 研究议程。

DESCRIPTION (adapted from applicant's abstract): The scientific focus of the University of Texas Southwestern Medical Center AIDS Clinical Trials Unit (UTSMC ACTU) will be on the immunopathogenesis of HIV infection and immune reconstitution of patients treated with HAART. Specific areas of expertise include the role of the adult thymus in immune reconstitution of patients on HAART, the role of HIV-specific CD4+ and CD8+ T cell responses in the control of HIV replication in patients who are, and are not, treated for HIV infection, and the role of immune activation in HIV immunopathogenesis. In addition, investigators at UTSMC ACTU have extensive expertise in lipodystrophies, which they will bring to the study of protease inhibitor-induced lipodystrophy. Given the strengths in both clinical and basic science, they feel that the proposed UTSMC ACTU will serve as an integral part of the AACTG's mission to develop novel and effective treatments for HIV infection through a better understanding of the mechanisms underlying the pathogenesis of HIV-induced illness. The overall goal of the UTSMC ACTU will be to contribute to the mission of the AACTG. This will involve the enrolling and retention of appropriate patients into clinical trials developed within the framework of the AACTG. These patients will include all members of the diverse population served by the clinical facilities. More importantly, they envision being active participants in the scientific research agenda of the AACTG, and will contribute substantially to its knowledge base and future direction. In order to complete this goal, the specific aims of the UTSMC ACTU will be: (1) to contribute to the HIV disease research agenda; (2) to contribute to the complications of HIV disease research agenda; (3) to contribute to the immunology research agenda; and (4) to contribute to other research agendas.