HCV VIRAL DECAY DURING THERAPY IN THOSE CO-INFECTED WITH HCV AND HIV

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项试验性研究的目的是：1）前瞻性评价HIV/HCV合并感染受试者与HCV单一感染受试者相比早期病毒动力学参数和病毒学应答率的差异2）评价治疗前和治疗期间HIV/HCV合并感染受试者与HCV单一感染受试者相比HCV准种多样性的差异3）评估外周血淋巴细胞的HCV复制肝外位点4）评估HIV/HCV与HCV单一感染相比的HCV相关免疫应答。 本研究的假设是HIV和HCV之间的相互作用可能会损害HIV/HCV受试者对HCV治疗的宿主应答。 本项目是一项试点研究，为提交K23文件做准备

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this pilot study are: 1) to prospectively evaluate the differences in early viral kinetic parameters and virologic response rates in HIV/HCV co-infected subjects compared to HCV mono-infected subjects 2) to evaluated differences in HCV quasi-species diversity in HIV/HCV co-infected subjects before and during treatment in comparison to HCV mono-infected subjects 3) to evaluate peripheral blood lymphocytes for extrahepatic site of HCV replication 4) to evaluate the HCV related immune response in HIV/HCV compared to HCV mono-infection. The hypothesis of the study is that interaction between the HIV and HCV may impair the host response to HCV therapy in HIV/HCV subjects. This project is a pilot study in preparation for a K23 submission