NCI CFRBCCS INFORMATICS CENTER AT UCI

描述：先进的突变检测技术，克隆 几个癌症易感基因，以及基因的高通量测序 使以前的许多过时的研究和目前的一些研究 癌症遗传流行病学的策略。此外，临床上的 遗传突变的影响将需要定义和传达 提供给医疗保健提供者和癌症遗传学专业人士。要提供一个 人类癌症遗传学研究的基础设施规模空前 和复杂性，国家癌症研究所发起了合作社 乳腺癌和结肠癌研究家庭登记(CFRBCCS)。集成到 这将是一个最先进的信息学中心(IC)，它将 开发、实施和维护中央信息学系统，并提供 信息技术发展方面的技术专长， 统计方法和研究设计。总体而言，芝加哥大学 加州大学欧文分校、达特茅斯医学院和加州大学 南加州在开发信息方面拥有丰富的经验 管理系统，参与和协调多中心研究 努力，并开发生物统计方面的先进技术。此外， 国际领先的生物统计学、遗传流行病学和 分子遗传学将作为成员参与生物统计学， 遗传学和流行病学联合会，提供技术专长，以 CFRBCCS研究人员。我们的具体目标是：1)开发、实施和 在UCI维护单一的中央信息系统，2)提供摘要 为CFRBCCS登记册提供数据、支持和协调，3)提供 在统计问题、研究设计、方法、 和信息技术，通过一项国际合作 生物统计学、遗传流行病学和 分子遗传学，4)落实CFRBCCS责任 学习范围内的沟通、协调和行政职责。

DESCRIPTION: Advanced technology for mutation detection, the cloning of several cancer susceptibility genes, and high-throughput sequencing of genes make obsolete many of the previous and some of the current research strategies in the genetic epidemiology of cancer. In addition, the clinical implications of inherited mutations will need to be defined and communicated to health care providers and cancer genetics professionals. To provide an infrastructure for studies in human cancer genetics of unprecedented size and complexity, the National Cancer Institute has initiated the Cooperative Family Registry for Breast and Colon Cancer Studies (CFRBCCS). Integral to this effort will be a state-of-the-art Informatics Center (IC), that will develop, implement, and maintain a central informatics system and provide technical expertise for the development of information technologies, statistical methodology, and study design. Collectively, the University of California at Irvine (UCI), Dartmouth Medical School, and the University of Southern California have extensive experience in developing information management systems, participating in and coordinating multi-center research efforts, and developing advanced techniques in biostatistics. Further, leading international experts in biostatistics, genetic epidemiology, and molecular genetics will participate as members in the Biostatistics, Genetics, and Epidemiology Consortium, to provide technical expertise to CFRBCCS researchers. Our specific aims are: 1) Develop, implement, and maintain a single central informatics system at UCI, 2) Provide summary data, support, and coordination for the CFRBCCS registries, 3) Provide technical expertise regarding statistical issues, study design, methodology, and information technologies for the Registries, through an international consortium of leading experts in biostatistics, genetic epidemiology, and molecular genetics, 4) Carry out the responsibility for the CFRBCCS Study-wide communication, coordination, and administrative duties.