Functional studies on a neuroprotective activity of the amyloid precursor protein of Alzheimer s disease.

阿尔茨海默病淀粉样前体蛋白的神经保护活性的功能研究。

• 批准号: nhmrc : 145761
• 负责人: Prof David Small
• 金额: $ 10.7万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-studies-neuroprotective-s-disease/76031
• 关键词: Functional; studies; neuroprotective; activity; amyloid

Alzheimer's disease is a major health problem of the elderly. With our aging population living longer, this presents enormous economic and social pressures. Research into the mechanism of Alzheimer's disease is therefore of immediate importance. In this study we are trying to determine the relationship between proteins involved in the disease process. In particular we are studying the amyloid precursor protein (APP). APP has both therapeutic as well as disease causing actions. It gives rise to the toxic amyloid peptide Abeta which is responsible for disease. However APP can also inhibit Abeta toxicity thus controlling cell death. We are studying how APP is able to modulate the neurotoxic activity of Abeta. These studies will identify key aspects of the disease pathway and hopefully lead to treatment strategies.

阿尔茨海默病是老年人的主要健康问题。随着人口老龄化的加剧，这对经济和社会造成了巨大的压力。因此，研究阿尔茨海默病的机制具有直接的重要性。在这项研究中，我们试图确定参与疾病过程的蛋白质之间的关系。特别是我们正在研究淀粉样前体蛋白（APP）。APP既有治疗作用，也有致病作用。它会产生有毒的淀粉样肽Abeta，这是疾病的原因。然而，APP也可以抑制Abeta毒性，从而控制细胞死亡。我们正在研究APP如何能够调节Abeta的神经毒性活性。这些研究将确定疾病途径的关键方面，并有望导致治疗策略。