A Novel Neuroprotectant to Reduce Ischemic Injury
一种减少缺血性损伤的新型神经保护剂
基本信息
- 批准号:10576568
- 负责人:
- 金额:$ 40.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:12-HETEAdhesivesAlteplaseArachidonate 15-LipoxygenaseArachidonic AcidsBindingBiological AssayBloodBolus InfusionBrainBrain InjuriesBrain IschemiaCause of DeathCerebrovascular systemCharacteristicsClinicalClinical ResearchCorrelation StudiesDataDoseDrug KineticsEdemaEffectivenessEnzymesExcisionFDA approvedFormulationFutureGoalsHemorrhageHigh Pressure Liquid ChromatographyHumanHydroxyeicosatetraenoic AcidsIn VitroInfarctionInfusion proceduresIntravenousIntravenous infusion proceduresIschemic StrokeLeadLipoxygenaseMeasuresModelingMorbidity - disease rateNeuronsNeuroprotective AgentsOutcomeOutcome StudyPharmaceutical ChemistryPharmaceutical PreparationsPharmacotherapyPhasePlasmaPublic HealthRattusRecombinantsReperfusion TherapyRodentRouteSamplingSiteStandardizationStrokeTestingTherapeutic AgentsTimeUnited StatesWalkingbehavior testbrain endothelial celldosageeffective therapyefficacy testingexperimental studyin vivoinhibitorintraperitonealintravenous administrationischemic injurymortalitymouse modelmultimodalityneuron lossnovelnovel therapeuticsoxidationpharmacodynamic biomarkerpharmacokinetics and pharmacodynamicspharmacologicresponsescaffoldside effectsmall molecule inhibitorspecific biomarkersstroke modelstroke patientstroke therapytherapeutically effectivethromboembolic strokethrombolysis
项目摘要
The goal is to develop novel therapeutics effective in stroke. This will be achieved by providing evidence for in
vivo activity of our lead compound in a rat stroke model as well as supportive pharmacokinetic and
pharmacodynamic (PK/PD) assay data. We have identified potent and highly selective inhibitors of the human
12/15 lipoxygenase enzyme, which contributes to brain injury after a stroke by damaging neurons and
endothelial cells of the brain. We now want to test our lead compound in a rat model of ischemic stroke, to
determine the optimal dosage and time of administration. The effectiveness of the inhibitor will be determined
by measuring infarct sizes, as well as the enzyme products formed by 12/15 lipoxygenase in the presence or
absence of its inhibitor. These results will then be correlated to the brain exposure achieved by the inhibitor at
different dosages. Successful completion of these studies will ready our lead compound for subsequent IND-
enabling studies, to advance our lead molecule toward clinical utility as novel stroke therapy.
目标是开发对中风有效的新疗法。这将通过为in提供证据来实现
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KLAUS VAN LEYEN其他文献
KLAUS VAN LEYEN的其他文献
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{{ truncateString('KLAUS VAN LEYEN', 18)}}的其他基金
Testing the Lipoxygenase Inhibitor BPN-27332 as Acute Phase Stroke Treatment in the SPAN Network
在 SPAN 网络中测试脂氧合酶抑制剂 BPN-27332 作为急性期中风治疗的作用
- 批准号:
10671991 - 财政年份:2023
- 资助金额:
$ 40.84万 - 项目类别:
Development of human 12/15-lipoxygenase therapeutics for stroke
开发人类 12/15-脂氧合酶治疗中风的药物
- 批准号:
9898504 - 财政年份:2018
- 资助金额:
$ 40.84万 - 项目类别:
Development of human 12/15-lipoxygenase therapeutics for stroke
开发人类 12/15-脂氧合酶治疗中风的药物
- 批准号:
9922389 - 财政年份:2018
- 资助金额:
$ 40.84万 - 项目类别:
Novel 12/15 lipoxygenase inhibitors for the treatment of stroke
用于治疗中风的新型 12/15 脂氧合酶抑制剂
- 批准号:
8684486 - 财政年份:2014
- 资助金额:
$ 40.84万 - 项目类别:
Novel 12/15 lipoxygenase inhibitors for the treatment of stroke
用于治疗中风的新型 12/15 脂氧合酶抑制剂
- 批准号:
8846695 - 财政年份:2014
- 资助金额:
$ 40.84万 - 项目类别:
Effects of Semaphorin 3A on Stroke Recovery
Semaphorin 3A 对中风恢复的影响
- 批准号:
8470260 - 财政年份:2011
- 资助金额:
$ 40.84万 - 项目类别:
Effects of Semaphorin 3A on Stroke Recovery
Semaphorin 3A 对中风恢复的影响
- 批准号:
8305479 - 财政年份:2011
- 资助金额:
$ 40.84万 - 项目类别:
Effects of Semaphorin 3A on Stroke Recovery
Semaphorin 3A 对中风恢复的影响
- 批准号:
8041869 - 财政年份:2011
- 资助金额:
$ 40.84万 - 项目类别:
12/15-Lipoxygenase and neurovascular damage following cardiac arrest
心脏骤停后的 12/15-脂氧合酶和神经血管损伤
- 批准号:
8318072 - 财政年份:2005
- 资助金额:
$ 40.84万 - 项目类别:
12/15-Lipoxygenase and neurovascular damage following cardiac arrest
心脏骤停后的 12/15-脂氧合酶和神经血管损伤
- 批准号:
8239055 - 财政年份:2005
- 资助金额:
$ 40.84万 - 项目类别:
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