Synthesis of Biodegradable and Functionalisable Polyesters for the delivery of active ingredients

用于输送活性成分的可生物降解和可官能化聚酯的合成

• 批准号: 2775107
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2775107
• 关键词: Synthesis; Biodegradable; Functionalisable; Polyesters; delivery

The overwhelming majority of commercial polymeric excipients are derived from petrochemical sources and lack the versatility needed to be exploited by emerging areas of commercial importance. Historically, the drug-delivery field has made only limited efforts towards green synthetic strategies and miniaturised, low-wastage formulation screening. Now, there is a real drive towards developing scalable transformations to exploit natural resources and waste into truly sustainable polymers To tackle this lack of available "smart" materials, we will exploit natural multifunctional building blocks, developing a library of renewable and degradable polymers with highly tuneable functionalities. All of this will be done using green and selective catalysts.These sustainable polymers will be tested as polymeric (nano) delivery devices, to encapsulate active ingredients (AIs) using a miniaturised approach to eliminate waste.

绝大多数商业聚合物赋形剂来源于石油化学来源，缺乏新兴商业重要性领域所需的通用性。从历史上看，药物递送领域仅在绿色合成策略和简化的低浪费制剂筛选方面做出了有限的努力。现在，有一个真实的驱动力，发展可扩展的转换，利用自然资源和废物转化为真正可持续的聚合物为了解决缺乏可用的“智能”材料的问题，我们将利用天然的多功能构建模块，开发具有高度可调功能的可再生和可降解聚合物库。所有这些都将使用绿色和选择性催化剂来完成。这些可持续的聚合物将作为聚合物（纳米）输送装置进行测试，以使用一种消除浪费的方法来封装活性成分（AI）。