I-Corps: Biodegradable Regenerative Spinal Implants
I-Corps:可生物降解的再生脊柱植入物
基本信息
- 批准号:2319774
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this I-Corps project is to improve treatment and outcomes of spinal cord injury. Annually, approximately 18,000 people in the United States and between 250,000 to 500,000 people globally suffer a spinal cord injury not only as a result of traumatic injuries but also from vascular damage and infections. Depending upon the degree of severity, spinal cord injury patients face lengthy, if not permanent disabilities, often with lifetime medical costs exceeding million dollars. Currently, there are no curative treatment for spinal cord injury while extensive and expensive rehabilitative therapy is the only option for many patients. Advances in surgical interventions have progressed beyond classic decompression and stabilization to grafts which can provide limited improvements in nerve regeneration, but new experimental approaches can be technically challenging and costly while recovery times can remain painfully long. The proposed technology aims to reduce the cost and complexities of neural repair surgery by offering a simple to use and readily available tissue scaffold, while improving long term outcomes by promoting neuronal regrowth. This I-Corps project is based on the development of biodegradable bioactive materials for tissue regeneration, controlled drug delivery, stem cell therapies, medical implants and devices. Nerve injuries are among the most difficult injuries to heal because under normal physiological conditions, mature neurons do not undergo cell division. Tissue grafts are the standard of care for surgical intervention in nerve injuries, however limitations on donor availability, as well as tissue mismatches and damage to the graft site represent serious drawbacks to these procedures. Alternatively, synthetic nerve guidance conduit or channel devices made from different materials have been approved for clinical use, but such devices fail to match the functional recovery of traditional nerve grafting procedures. This project builds upon existing nerve guidance conduit or channel devices by incorporating biocompatible bioactive microwires to improve neural healing. This new device is naturally biodegradable and bioresorbable in the body, mechanically matching neural tissue, and electrically conductive for neural stimulation and controlled release of neuroprotective ions. This bioresorbable neural device does not require removal surgery as it degrades in a natural and safe manner. Overall, the integration of bioactive microwires into nerve guidance conduit or channels can accelerate neural recovery process and improve functional outcome while eliminating the need for additional surgery.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个I-Corps项目更广泛的影响/商业潜力是改善脊髓损伤的治疗和结果。每年,美国约有18,000人,全球约有250,000至500,000人遭受脊髓损伤,不仅是由于创伤性损伤,而且还由于血管损伤和感染。根据严重程度,脊髓损伤患者面临长期的,如果不是永久性的残疾,往往与终身医疗费用超过百万美元。目前,脊髓损伤没有治愈性治疗,而广泛和昂贵的康复治疗是许多患者的唯一选择。手术干预的进展已经超越了经典的减压和稳定移植,这可以提供有限的改善神经再生,但新的实验方法可能在技术上具有挑战性和昂贵的,而恢复时间可能仍然很长。所提出的技术旨在通过提供简单易用且易于获得的组织支架来降低神经修复手术的成本和复杂性,同时通过促进神经元再生来改善长期结果。这个I-Corps项目的基础是开发可生物降解的生物活性材料,用于组织再生、受控药物输送、干细胞治疗、医疗植入物和设备。神经损伤是最难治愈的损伤之一,因为在正常生理条件下,成熟的神经元不进行细胞分裂。组织移植物是神经损伤中外科手术干预的护理标准,然而供体可用性的限制以及组织错配和移植部位的损伤代表了这些手术的严重缺点。或者,由不同材料制成的合成神经引导导管或通道装置已被批准用于临床使用,但此类装置无法匹配传统神经移植手术的功能恢复。该项目建立在现有的神经引导导管或通道装置,通过结合生物相容性生物活性微丝,以改善神经愈合。这种新设备在体内是自然可生物降解和生物可吸收的,机械匹配神经组织,并具有导电性,可用于神经刺激和神经保护离子的受控释放。这种生物可吸收神经器械不需要进行移除手术,因为它以自然和安全的方式降解。总的来说,将生物活性微导线整合到神经引导导管或通道中可以加速神经恢复过程并改善功能结果,同时无需额外的手术。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Huinan Liu其他文献
Magnesium-Based Bioresorbable Implants for Craniomaxillofacial and Orthopaedic Operations: In Vivo Studies in Rats
- DOI:
10.1016/j.jamcollsurg.2021.07.427 - 发表时间:
2021-11-01 - 期刊:
- 影响因子:
- 作者:
Nolan Winicki;Jiajia Lin;Patricia Holt-Torres;Raj Vyas;Arash Aslani;Eric Tobin;Huinan Liu - 通讯作者:
Huinan Liu
Microstructure and properties of FeCoNiCrX (Ximg class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/dbnd" /Mn, Al) high-entropy alloy coatings
- DOI:
10.1016/j.jallcom.2022.166061 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:6.300
- 作者:
Zhiyi Rong;Chaohui Wang;You Wang;Meiling Dong;Yuan You;Jianing Wang;Huinan Liu;Jiaqi Liu;Yuhang Wang;Zhongyu Zhu - 通讯作者:
Zhongyu Zhu
A study on how social media influences on impulsive buying
社交媒体如何影响冲动购买的研究
- DOI:
10.1111/exsy.13448 - 发表时间:
2023 - 期刊:
- 影响因子:3.3
- 作者:
Huinan Liu;Mohd Feroz Shah De Costa Bin Mohd Faris De Costa;Megat Al‐lmran Bin Yasin;Qijie Ruan - 通讯作者:
Qijie Ruan
Multiple nuclear receptor-regulated endocrine disrupting effects: A case study for bisphenol-induced crosstalk between RARα and ERα signaling pathways
多种核受体调节的内分泌干扰效应:双酚类诱导的 RARα 和 ERα 信号通路串扰的案例研究
- DOI:
10.1016/j.jhazmat.2025.139005 - 发表时间:
2025-09-05 - 期刊:
- 影响因子:11.300
- 作者:
Jiahui Su;Qian S. Liu;Xiaoxi Yang;Hanqing Xu;Mengyao Bing;Huinan Liu;Qunfang Zhou;Guibin Jiang - 通讯作者:
Guibin Jiang
An Investigation of High School Students’ Attitudes and Perceptions About the Diversity of Scientific Methods in Chemistry Learning
- DOI:
10.1007/s11191-024-00589-x - 发表时间:
2024-11-06 - 期刊:
- 影响因子:2.500
- 作者:
Huinan Liu;Bo Chen;Jia Ma;Manting Zhang;Chenyue Yang - 通讯作者:
Chenyue Yang
Huinan Liu的其他文献
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{{ truncateString('Huinan Liu', 18)}}的其他基金
I-Corps: Novel Biodegradable Metals and Biomimetic Interfaces with Enhanced Strength and Bioactivity
I-Corps:新型可生物降解金属和仿生界面,具有增强的强度和生物活性
- 批准号:
1840332 - 财政年份:2018
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
UNS: Engineering Infection-Free Implants for Skeletal Reconstruction
UNS:用于骨骼重建的无感染植入物工程
- 批准号:
1512764 - 财政年份:2015
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
BRIGE: An Interdisciplinary Research and Education Program for Engineering Biodegradable Metallic Implants and Biomimetic Interfaces
BRIGE:可生物降解金属植入物和仿生界面工程的跨学科研究和教育计划
- 批准号:
1125801 - 财政年份:2011
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
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