Metal free Arylation in Biological Systems

催化的系统方法正在成为生物技术行业中所有分子（药物、农用化学品、商品、分子探针等）合成的框架。这种未来的合成将以一种联合和连贯的方式利用整个生物体（合成生物学），生物催化和化学催化，从而使合成路线在成本，环境足迹和合成效率方面大大简化。这将需要新的工作方式;拟议的多学科项目提供化学、生物学和分析科学方面的培训，为工业生物技术采取更加系统主导的办法创造必要的工作环境。该项目建议将最先进的生物缀合系统转化为生产生物技术构件，在化学和生物学的界面上提供真正的当代博士培训经验。

A systems approach to catalysis is emerging as the framework under which all molecules (drugs, agrochemicals, commodities, molecular probes etc) in the biotechnology industry will be synthesised. This future synthesis will utilise whole organisms (synthetic biology), biocatalysis and chemo-catalysis in a joined-up and coherent fashion, such that synthetic routes are dramatically streamlined in terms of costs, environmental footprint and synthetic efficiency. This will require new ways of working; the proposed multi-disciplinary project offers training in chemistry, biology and analytical science that will produce the working environment necessary for a more systems-led approach to industrial biotechnology. The project proposes to translate state of the art bioconjugation systems in to produce biotechnology building blocks, providing a truly contemporary PhD training experience at the interface of chemistry and biology.