Social & Language Deficits in Autism-Biology & Treament

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• 批准号: 7118061
• 负责人: MARIAN D SIGMAN
• 金额: $ 150.87万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-13 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118061
• 关键词: autism; child mental disorders; clinical research; cooperative study; human subject; interpersonal relations; psycholinguistics; social behavior

The goal of the UCLA Center for Autism Research and Treatment (CART) is to conduct basic research on genetics, brain structure and function, and behavioral development as well as experimental interventions in order to understand the biological bases and possible environmental remedies for core deficits in autism. The central theme of the UCLA CART is on the elucidation of the etiology of social, communicative, and language deficits in autism, and the second theme is on the design and testing of experimental interventions. The specific aims of the CART research are to 1) Identify the abilities and characteristics, both behavioral and genetic, which differentiate the infant siblings of children with autism from siblings of developmentally delayed and typically developing siblings and predict the later manifestations of autistic symptoms; 2) Determine the neural pathways used by children with autism and typically developing children in understanding prosody and language; 3) Implement and compare the effects of intervention projects aimed at ameliorating behavioral disturbances and improving interactions with family members, peers, and friends; and 4) Define the genetic contributions to autism by studying component cognitive and behavioral endophenotypes and performing specific genotype - phenotype correlations, thereby, laying the groundwork for future pharmacogenetic studies. Besides providing resources to the projects, each Core will have a unique educational component. The Administrative-Database Core will contain a Pilot Program; the Imaging Core will develop means for teaching their techniques to a wider group of autism researchers; and the Assessment and Outreach Core will organize an educational program for Center members as well as for the community groups with whom we are cooperating.

加州大学洛杉矶分校自闭症研究和治疗中心(CART)的目标是对自闭症的遗传学、大脑结构和功能、行为发育以及实验干预进行基础研究，以了解自闭症核心缺陷的生物学基础和可能的环境补救措施。加州大学洛杉矶分校CART的中心主题是阐明自闭症中社交、交流和语言缺陷的病因，第二个主题是实验干预的设计和测试。CART研究的具体目的是：1)确定自闭症儿童的婴儿兄弟姐妹与发育迟缓儿童的兄弟姐妹在行为和遗传方面的能力和特征 该项目的目的是：1)确定自闭症儿童在理解韵律和语言方面所使用的神经通路；3)实施并比较旨在改善行为障碍和改善与家庭成员、同龄人和朋友的互动的干预项目的效果；4)通过研究自闭症患者的认知和行为内表型并进行特定的基因-表型关联，确定自闭症的遗传贡献。除了为项目提供资源外，每个核心都将有一个独特的 教育部分。管理数据库核心将包含一个试点计划；成像核心将开发向更广泛的自闭症研究人员传授他们的技术的手段；评估和外联核心将为中心成员以及与我们合作的社区团体组织一个教育计划。