The development and characterization of biomimetic phantom Objective

仿生体模的开发与表征

• 批准号: 2841055
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2841055
• 关键词: development; characterization; biomimetic; phantom; Objective

Objective 1.The development and characterization of biomimetic phantomThe rapid development of an optical imaging technique called multispectral imaging(MSI) in recent years could improve the total tumor resection during glioma surgical resection. To evaluate the ability of the MSI system to detect fluorescence, optical phantoms that mimic tissues have been created. Optical phantoms have been used to mimic some complex structures, but still have limitations in mimicking structures such as the brain. In this study, gel wax-based fluorescent phantoms that simulate brain gray matter, white matter, glioma, and 25 different brain tissues will be created. A novel MSI system developed in SIE will be used to detect the fluorescence of phantoms. Based the result from MSI system, these optical phantoms will be evaluated to be the standard for testing the MSI system.Objective 2.Developing a light field optical imaging system for surgical guidanceLight-field imaging(LFI) employs a microlens array to capture both planar and angular information of light rays in a single snapshot, which can be post-processed to produce a 3D reconstruction of the scene. Compared to other 3D imaging systems, the advantage of light field imaging is the ability to refocus after the image captured and to obtain depth information. In this project,an intraoperative LFI system will be developed to provide surgeons with a 3D view of the surgical scene, and to reconstruct the tumour profile (including location, margins and depth). In the project, ray optics simulations will be carried out by using software to optimise the configuration of main lenses, relay lenses, and microlens array. The pitch size and f-number of the microlens array will be optimised in particular to achieve the desired depth and lateral resolution for neurosurgical guidance. Using an epipolar-plate-image-based approach, light field data acquired with monochromatic illumination will be processed to estimate depth information.

目的1.仿生体模的发展及其特征近年来一种称为多光谱成像(MSI)的光学成像技术的迅速发展，有助于提高脑胶质瘤手术切除时的肿瘤全切率。为了评估MSI系统检测荧光的能力，人们创造了模拟组织的光学模体。光学幻影已经被用来模拟一些复杂的结构，但在模拟大脑等结构方面仍然存在局限性。在这项研究中，将创建基于凝胶蜡基的荧光模体，模拟大脑灰质、白质、胶质瘤和25种不同的脑组织。在SIE开发的一种新的MSI系统将用于探测模体的荧光。目的：研制一种用于手术指导的光场光学成像系统光场成像(LFI)利用微透镜阵列捕捉单次快照中光线的平面和角度信息，并对其进行后处理以生成场景的3D重建。与其他3D成像系统相比，光场成像的优势在于能够在捕获图像后重新聚焦并获得深度信息。在这个项目中，将开发一个术中LFI系统，为外科医生提供手术场景的3D视图，并重建肿瘤轮廓(包括位置、边缘和深度)。在该项目中，将利用软件进行光线光学模拟，以优化主透镜、接力透镜和微透镜阵列的配置。微透镜阵列的节距、大小和f数将被特别优化，以达到神经外科指导所需的深度和横向分辨率。使用基于极板图像的方法，对单色照明获取的光场数据进行处理以估计深度信息。