NSF/FDA Scholar In Residence: Quantitative Characterization of Near-infrared Fluorescence Molecular Imaging Systems: 3D-printed Biomimetic Phantoms and In vivo Validation

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ABSTRACTPI: Chen, Yu Proposal Number:1641077 The PI will develop advanced methods for characterizing minimally-invasive diagnostic medical devices. The research will facilitate the development and standardized performance testing of novel biophotonic technologies for early disease detection and image-guided surgery. 3D-printed biomimetic phantoms for the performance testing of near-infrared spectroscopy systems (NIRS) will be developed and the PI will investigate near-infra-red (IR) fluorescence (NIRF) image quality through in vivo and phantom-based measurements to explore the basis for developing standards that can be used to validate NIRF imaging systems. The development of novel biomimetic phantoms for noninvasive fluorescence molecular imaging (FMI) will elucidate optimal fabrication approaches that influence the effectiveness of 3D-printed phantoms.