Oxide Glass Fiber Optimized for Short Pulse IR Lasers

针对短脉冲红外激光器优化的氧化物玻璃光纤

• 批准号: 7125969
• 负责人: DANH C TRAN
• 金额: $ 34.78万
• 依托单位: INFRARED FIBER SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125969
• 关键词: biomaterial development /preparation; biomedical equipment development; biotechnology; clinical biomedical equipment; fiber optics; germanium; infrared radiation; laser therapy; lasers; oxides

DESCRIPTION (provided by applicant): There is a clinical need for optimized fiber transmission of short pulse mid-IR laser radiation for surgical applications. Large potential markets such as skin resurfacing, dentistry, and ophthalmology utilize the Er:YSGG (2.79 mu/m) and Er:YAG (2.94 mu/m) lasers for therapeutic procedures. These lasers are capable of efficiently and precisely ablating both hard and soft tissues while avoiding the peripheral thermal damage and necrosis observed at other wavelengths. During Phase I, we developed an improved germanium fiber for short pulse and high power delivery by removal of bubbles, striation, and particles from the glass and began the development of a biocompatible fiber. Fiber transmission and fiber damage thresholds were determined at both short (500-ns) and long (8-300 us) pulse lengths, and laser parameters were optimized for efficient soft tissue ablation. Hybrid fibers consisting of silica and sapphire tips attached to a trunk fiber were developed to prevent damage of the fiber during contact tissue ablation, and tested for high power laser transmission. Phase II work will consist of six specific aims: (1) Improvement of the power handling and yield of germanium fibers by reducing remaining glass defects and improved fiber tip polishing. (2) Development of high performance and reliable germanium fibers from compositions that are biocompatible and pass the MEM cytotoxicity and intracutaneous injection tests, and study methods of fiber sterilizaton, such as autoclave and EtO. (3) Development of specialized fiber probe tip designs consisting of hybrid germanium/silica fibers, end caps, micro-lenses, side-firing fibers, and sculpted fiber tips, for flexible delivery of radiation during custom surgical procedures involving contact and non-contact laser tissue ablation. (4) Improvement of the Erbium laser spatial and temporal beam profile to provide higher fiber damage thresholds at the input/output ends of the fiber. (5) Q-switched ErYSGG transmission through fibers and specialty tips with measurement of the tissue ablation rates and quantification of the peripheral thermal and mechanical side effects. (6) Ablation of hard cataracts and precise incision of other, soft ophthalmic tissues for potential clinical applications using fiber delivery of short-pulse Er:YAG energy.

描述（由申请人提供）：

项目成果

Comparison of germanium oxide fibers with silica and sapphire fiber tips for transmission of erbium: YAG laser radiation.

用于传输铒：YAG 激光辐射的氧化锗光纤与二氧化硅和蓝宝石光纤尖端的比较。

• DOI: 10.1002/lsm.20382
• 发表时间: 2006
• 期刊: Lasers in surgery and medicine
• 影响因子: 2.4
• 作者: Polletto,TravisJ;Ngo,AnthonyK;Tchapyjnikov,Alexei;Levin,Ken;Tran,Danh;Fried,NathanielM
• 通讯作者: Fried,NathanielM

Side-firing germanium oxide optical fibers for use with erbium:YAG laser.

用于铒：YAG 激光器的侧射氧化锗光纤。

• DOI: 10.1089/end.2006.20.475
• 发表时间: 2006
• 期刊: Journal of endourology
• 影响因子: 2.7
• 作者: Ngo,AnthonyK;Fried,NathanielM
• 通讯作者: Fried,NathanielM