A Compact X-ray Station for Protein Crystallography

描述（由申请人提供）：此快速通道SBIR的目的是开发用于大分子晶体学的创新型紧凑型x射线站（CXS）。该站接受小型同步加速器紧凑型光源输出的x射线束，并将x射线束输送到3个末端站。每个光束线可容纳一个集成的商用衍射仪。每2侧站接收可调，单色x射线束在一个30微米的均方根点。前站接收聚焦的高通量窄带x射线束。每个x射线束可在7到16 keV之间进行调节，并将提供与同步加速器光束线相当的通量和能量分辨率。光束线可以单独运行，成对运行，也可以同时运行。在第一阶段，我们将设计x射线光学系统，并实验测试一种新的可调聚焦单色仪。在第二阶段，我们将建设x射线光学和端站，整合商用衍射仪并对端站进行全面测试。xs是一种创新的，强大的，“交钥匙”x射线系统，将为大分子晶体学提供3个“同步加速器”光束线的家庭实验室；2条光束线将具有通量、可调性和能量分辨率，用于单波长或多波长异常色散实验，第三条光束线将进行优化，用于更高通量的筛选。

DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.