A Compact X-ray Station for Protein Crystallography

用于蛋白质晶体学的紧凑型 X 射线站

• 批准号: 7091930
• 负责人: JEFFREY RIFKIN
• 金额: $ 244.95万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7091930
• 关键词: X ray crystallography; bioengineering /biomedical engineering; biomedical equipment development; electromagnetic radiation; macromolecule; miniature biomedical equipment; optics; synchrotrons

DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.

描述（由申请人提供）：该快速通道SBIR的目的是开发用于大分子晶体学的创新紧凑型X射线站（CXS）。该站接受紧凑型光源（一种微型同步加速器）的输出X射线束，并将X射线束输送到3个终端站。每条光束线都可容纳一个集成的商用衍射仪。2个侧站中的每一个接收30微米rms光斑中的可调谐单色X射线束。前站接收聚焦的高通量窄带X射线束。每个X射线束可从7到16 keV调谐，并将提供与同步加速器光束线相当的通量和能量分辨率。光束线可以单独运行，成对或同时运行。在第一阶段，我们将设计X射线光学系统和实验测试一个新的，可调聚焦单色器。在第二阶段，我们将建造X射线光学系统和终端站，集成商用衍射仪并对终端站进行全面测试。CXS是一款创新、功能强大的“交钥匙”X射线系统，将为家庭实验室提供3条用于大分子晶体学的“同步加速器”光束线; 2条光束线将具有单波长或多波长异常色散实验的通量、可调性和能量分辨率，第三条光束线将针对更高通量的筛选进行优化。