A Compact X-ray Station for Protein Crystallography

用于蛋白质晶体学的紧凑型 X 射线站

• 批准号: 7472147
• 负责人: JEFFREY RIFKIN
• 金额: $ 169.03万
• 依托单位: LYNCEAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7472147
• 关键词: Architecture; Crystallography; Development; Elements; Facility Construction Funding Category; Grant; Home environment; Intercept; Laboratories; Light; Maintenance; Motion; National Institute of General Medical Sciences; Optics; Output; Phase; Production; Protein Structure Initiative; Proteins; Purpose; R44 grant; Range; Research Personnel; Resolution; Resources; Roentgen Rays; Running; Scientist; Screening procedure; Side; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Source; Spottings; Synchrotrons; System; Testing; Time; beamline; concept; design; innovation; programs; prototype; research study; structural biology

The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to three endstations. Each beamline accommodates an integrated commercial diffractometer. Each of two side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all three simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new,tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the endstations. The CXS is an innovative, powerful, 'turn key'x-ray system which will provide a home laboratory with three 'synchrotron' beamlines for macromolecular crystallography; two beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.

该快速通道SBIR的目的是开发一种创新的紧凑型x射线站（CXS）