A Compact X-ray Station for Protein Crystallography

这个快速通道SBIR的目的是开发一种创新的紧凑型X射线站（CXS）， 大分子晶体学该工作站接收Compact Light的输出X射线束 源，一个微型同步加速器，并提供x射线束到三个终端站。每条光束线 可容纳一个集成的商用衍射仪。两个侧站中的每一个接收一个 在30微米RMS光斑中的可调谐单色X射线束。前站接收一个 聚焦的高通量窄带X射线束每个X射线束可在7至16 keV之间调谐 并且将提供与同步加速器光束线相当的通量和能量分辨率。光束线 可以单独运行、成对运行或同时运行。在第一阶段，我们将设计出 光学系统和实验测试一种新的，可调聚焦单色器。在第二阶段，我们 将建立X射线光学和终端站，集成商业衍射仪，并全面测试 终端站该CXS是一个创新的，强大的，'转钥匙' X射线系统，将提供一个家 用于大分子晶体学的三条同步加速器光束线实验室;两条光束线 将具有用于单波长或多波长异常的通量、可调谐性和能量分辨率。 第三条光束线将进行优化，以进行更高通量的筛选。

The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to three endstations. Each beamline accommodates an integrated commercial diffractometer. Each of two side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all three simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new,tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the endstations. The CXS is an innovative, powerful, 'turn key'x-ray system which will provide a home laboratory with three 'synchrotron' beamlines for macromolecular crystallography; two beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.