课题基金 / 基金详情

项目摘要

项目成果

JEFFREY RIFKIN的其他基金

相似基金

相关文献

中文摘要
翻译
描述(由申请人提供):此快速通道SBIR的目的是开发用于大分子晶体学的创新型紧凑型x射线站(CXS)。该站接受小型同步加速器紧凑型光源输出的x射线束,并将x射线束输送到3个末端站。每个光束线可容纳一个集成的商用衍射仪。每2侧站接收可调,单色x射线束在一个30微米的均方根点。前站接收聚焦的高通量窄带x射线束。每个x射线束可在7到16 keV之间进行调节,并将提供与同步加速器光束线相当的通量和能量分辨率。光束线可以单独运行,成对运行,也可以同时运行。在第一阶段,我们将设计x射线光学系统,并实验测试一种新的可调聚焦单色仪。在第二阶段,我们将建设x射线光学和端站,整合商用衍射仪并对端站进行全面测试。xs是一种创新的,强大的,“交钥匙”x射线系统,将为大分子晶体学提供3个“同步加速器”光束线的家庭实验室;2条光束线将具有通量、可调性和能量分辨率,用于单波长或多波长异常色散实验,第三条光束线将进行优化,用于更高通量的筛选。
英文摘要
DESCRIPTION (provided by applicant): The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to 3 end stations. Each beamline accommodates an integrated commercial diffractometer. Each of 2 side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all 3 simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new, tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the end stations. The CXS is an innovative, powerful, 'turn key' x-ray system which will provide a home laboratory with 3 'synchrotron' beamlines for macromolecular crystallography; 2 beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.zemedi.2012.11.003
发表时间: 2013-09
期刊: Zeitschrift fur medizinische Physik
影响因子: 2
作者: [F. Schwab;S. Schleede;D. Hahn;M. Bech;J. Herzen;S. Auweter;F. Bamberg;K. Achterhold;A. Yildirim;A. Bohla;O. Eickelberg;R. Loewen;M. Gifford;R. Ruth;M. Reiser;K. Nikolaou;F. Pfeiffer;F. Meinel]
通讯作者: F. Schwab;S. Schleede;D. Hahn;M. Bech;J. Herzen;S. Auweter;F. Bamberg;K. Achterhold;A. Yildirim;A. Bohla;O. Eickelberg;R. Loewen;M. Gifford;R. Ruth;M. Reiser;K. Nikolaou;F. Pfeiffer;F. Meinel
A Compact X-ray Station for Protein Crystallography
  • 批准号:
    7691984
  • 项目类别:
  • 资助金额:
    $75.36万
  • 财政年份:
    2005
  • 负责人:
    JEFFREY RIFKIN
  • 依托单位:
A Compact X-ray Station for Protein Crystallography
  • 批准号:
    7091930
  • 项目类别:
  • 资助金额:
    $244.95万
  • 财政年份:
    2005
  • 负责人:
    JEFFREY RIFKIN
  • 依托单位:
A Compact X-ray Station for Protein Crystallography
  • 批准号:
    7472147
  • 项目类别:
  • 资助金额:
    $169.03万
  • 财政年份:
    2005
  • 负责人:
    JEFFREY RIFKIN
  • 依托单位:
A Tunable, Tabletop, Synchrotron Light Source
  • 批准号:
    6950646
  • 项目类别:
  • 资助金额:
    $29.48万
  • 财政年份:
    2002
  • 负责人:
    JEFFREY RIFKIN
  • 依托单位:
海外基金