THERMOSYPHON TARGETRY TO IMPROVE F-18 PET

热虹管目标改进 F-18 PET

• 批准号: 7113760
• 负责人: Bruce Wendell Wieland
• 金额: $ 38.39万
• 依托单位: BRUCE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2008-02-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113760
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; cost effectiveness; deoxyglucose; fluoride ion; heat; material; mathematical model; neoplasm /cancer radionuclide diagnosis; particle accelerators; positron emission tomography; proton beam; radiopharmacology; radiotracer; surface coating; technology /technique development

DESCRIPTION (provided by applicant): The overall objective of the proposed work is to reduce the cost of accelerator produced F-18 radiopharmaceuticals used in Positron Emission Tomography (PET), a Medicare-reimbursed nuclear medicine metabolic imaging modality used to diagnose, stage, and restage ten cancer indications. Annual PET scans (350,000+) are rapidly increasing, but CMS reimbursement for PET scans is decreasing 23% from $1774 in 2004 to $1371 in 2005. Twenty percent of the total cost is the radiopharmaceutical dose of F-18 fluorodeoxy glucose (FDG). Sustaining growth in the use of PET will thus benefit from reducing the cost of producing FDG. The goal of this project is to lower cost per dose by a factor of two through the use of our invention called the thermosyphon target, which can remove twice as much proton beam heat as the one kilowatt limit of present target technology. Removing more heat allows full use of the available proton beam current in the installed base of PET cyclotrons, thus at least doubling the production of O-18(p,n)F-18 for FDG (feasibility established by Phase I prototype target experiments using the 27 MeV proton beam of the positive-ion Duke University PET Facility cyclotron). Two additional thermosyphon targets were designed and built in Phase I as preparation for testing to their thermal limits in Phase II at other accelerators (one with beam power of nine kilowatts). This proposed high power target engineering is breaking new ground, and Phase n research may have to address difficult technical problems not previously encountered. Phase II aim 1 is beam testing to determine the thermal limits of the prototypes built in Phase I for two negative-ion proton cyclotrons with energies of 16 and 30 MeV. Aim 2 is correlating test results with predictive thermohydraulic models to design improvements. Aim 3 is developing material science technology to coat high thermal conductivity target body materials (Cu, Ag) with chemically inert refractory metals (Ta, Nb), in order to accommodate high beam power while maintaining viable labeling chemistry. Aim 4 is developing efficient methods of recovering F-18 fluoride ion from thermosyphon designs. Aim 5 is applying results of the previous aims to build and test additional improved prototypes. Aim 6 is the design and demonstration of a reliable high-performance target system suitable for widespread commercial use. Aim 7 is applying the thermohydraulic models to determine performance envelopes to dictate target system designs for a variety of accelerators. The goal of Phase III is to make this technology available for retrofit to appropriate existing accelerators (currently estimated at 70) and for use by manufacturers of new cyclotrons, thus implementing cost reduction of F-18 FDG by a factor of two or more to reduce total PET scan costs about 10%.

描述（由申请人提供）： 拟议工作的总体目标是降低用于正电子发射断层扫描（PET）的加速器生产的F-18放射性药物的成本，PET是一种医疗保险报销的核医学代谢成像模式，用于诊断，分期和重新分期十种癌症适应症。每年的PET扫描（350，000+）正在迅速增加，但CMS对PET扫描的报销从2004年的1774美元下降到2005年的1371美元，下降了23%。总成本的20%是F-18氟脱氧葡萄糖（FDG）的放射性药物剂量。因此，PET使用的持续增长将受益于降低生产FDG的成本。该项目的目标是通过使用我们的发明，即热虹吸靶，将每剂量的成本降低两倍，该热虹吸靶可以去除两倍于目前靶技术一千瓦极限的质子束热量。去除更多的热量允许充分利用PET回旋加速器的安装基础中的可用质子束流，因此至少使用于FDG的O-18（p，n）F-18的产量加倍（通过使用正离子杜克大学PET设施回旋加速器的27 MeV质子束的第一阶段原型靶实验建立的可行性）。两个额外的热虹吸目标的设计和建造在第一阶段作为准备测试的热限制在第二阶段在其他加速器（一个与9千瓦的光束功率）。这项高功率靶工程正在开辟新的领域，第n阶段的研究可能必须解决以前没有遇到过的困难技术问题。第二阶段的目标1是束流测试，以确定在第一阶段建立的两个负离子质子回旋加速器的能量为16和30兆电子伏的原型的热极限。目标2是将测试结果与预测热工水力模型相关联，以改进设计。目标3是开发材料科学技术，用化学惰性难熔金属（Ta，Nb）涂覆高热导率靶体材料（Cu，Ag），以适应高光束功率，同时保持可行的标记化学。目的4是开发从热虹吸管设计中回收F-18氟离子的有效方法。目标5是应用先前目标的结果来构建和测试额外的改进原型。目标6是设计和演示一种适合广泛商业用途的可靠的高性能靶系统。目标7是应用热工水力学模型来确定性能包线，以指导各种加速器的目标系统设计。第三阶段的目标是使这项技术可用于改造现有的适当加速器（目前估计有70个），并供新回旋加速器的制造商使用，从而将F-18 FDG的成本降低两倍或更多，使PET扫描总成本降低约10%。