THERMOSYPHON CYCLOTRON TARGETRY TO IMPROVE F-18 PET

热虹管回旋加速器目标改进 F-18 PET

• 批准号: 6736581
• 负责人: Bruce Wendell Wieland
• 金额: $ 10万
• 依托单位: BRUCE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736581
• 关键词: deoxyglucose; high energy particle; particle accelerators; positron emission tomography; technology /technique development; thermodynamics

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a metabolic imaging modality used to diagnose, stage, and restage seven Medicare-reimbursed cancer types. Currently ninty-six US cyclotrons proton-bombard stable enriched O-18 water, producing F-18 fluoride ion to synthesize F-18 fluorodeoxyglucose (FDG) used in 350,000 PET scans per year. Our goal is to significantly lower the cost of FDG and thereby lower the cost of PET scans by about 10%. CTI, EBCO, GE, and IBA cyclotrons (10-20 MeV) are capable of twice the beam power that can be dissipated by their targets. We seek to demonstrate feasibility of our thermosyphon target invention that may have the potential to double F-18 production and fully realize cyclotron potential. The thermosyphon beam and condenser volumes are loaded full of target water, sealed at the top, and run with beam while pressurized at the bottom with 30 atm He. This results in a heat transfer geometry much superior to conventional targets, which load partially and seal at the bottom, leaving a reflux void to be pressurized at the top. The thermosyphon self-regulates, moving liquid (displaced by thermal expansion and condenser steam) in and out the bottom port. The condenser steam space is in proportion to the beam power until beam strike liquid is invaded at the upper power limit. Foreign gas molecules impeding vapor transport are avoided. Aim 1 is demonstrating reliability of a new production thermosyphon target by running at Duke University Medical Center, four days a week for one month to support FDG synthesis for clinical PET and PET/CT scanning of 15-20 patients/day (beams at or above 30 microamps and F-18 yields at or above 70% theoretical). Duke F-18 production is predicted to improve from the current 600 mCi/hr to 2000 mCi/hr with the new thermosyphon target. Aim 2 is designing beta-test targets for cyclotrons capable of long runs at 1.0-1.5 kW beam power, namely a CS-15 (15 MeV, 10mm beam) at Anchorage, AK, and a domestic GE PETrace (16 MeV, 15mm beam). Aim 3 is fabrication and initial beam testing of beta-test targets at the two sites. Collaborators will cost-share fabrication, retaining possession in exchange for sharing operating experience and publication authorship. Phase II experiments will lead to a commercial product by measuring F-18 yields up to the power limit, and optimizing target depth and condenser geometry to minimize 0-18 water use.

描述（由申请人提供）： 正电子发射断层扫描（PET）是一种代谢成像模式，用于诊断、分期和重新分期七种医疗保险报销的癌症类型。目前，美国有96台回旋加速器质子轰击稳定的浓缩O-18水，产生F-18氟离子，合成F-18氟脱氧葡萄糖（FDG），每年用于350，000次PET扫描。我们的目标是显著降低FDG的成本，从而将PET扫描的成本降低约10%。CTI、EBCO、GE和IBA回旋加速器（10-20 MeV）的束流功率是其目标所能消耗的束流功率的两倍。我们试图证明我们的热虹吸目标发明的可行性，该发明可能具有使F-18产量加倍并完全实现回旋加速器潜力的潜力。热虹吸管梁和冷凝器体积充满目标水，在顶部密封，并在底部用30 atm He加压时与梁一起运行。这导致传热几何形状远远上级传统的目标，其部分加载并在底部密封，留下回流空隙在顶部加压。热虹吸管自我调节，移动液体（由热膨胀和冷凝器蒸汽取代）进出底部端口。冷凝器蒸汽空间与射束功率成比例，直到射束撞击液体在功率上限处侵入。避免了阻碍蒸汽传输的外来气体分子。目标1是通过在杜克大学医学中心运行一种新的生产热虹吸靶的可靠性，每周运行四天，持续一个月，以支持每天15-20名患者的临床PET和PET/CT扫描的FDG合成（束流等于或高于30微安，F-18产率等于或高于70%理论值）。杜克F-18的生产预计将从目前的600 mCi/hr提高到2000 mCi/hr，采用新的热虹吸目标。目标2是为能够在1.0-1.5千瓦束流功率下长期运行的回旋加速器设计β测试靶，即位于阿拉斯加安克雷奇的CS-15（15 MeV，10毫米束流）和国产GE PETrace（16 MeV，15毫米束流）。目标3是在这两个地点制造β测试靶并进行初始束流测试。合作者将分担制作成本，保留所有权，以换取分享操作经验和出版著作权。第二阶段的实验将通过测量F-18在功率极限下的产额，并优化目标深度和冷凝器几何形状，以最大限度地减少0-18的用水量，从而实现商业产品。