Multi-Resolution Corneal Topography (MRCT)

多分辨率角膜地形图 (MRCT)

• 批准号: 7114850
• 负责人: Edwin Jay Sarver
• 金额: $ 15.85万
• 依托单位: SARVER AND ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114850
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; computer program /software; computer system design /evaluation; cornea; diagnosis design /evaluation; digital imaging; eye disorder diagnosis; eye fundus photography; image enhancement; optics; three dimensional imaging /topography; vision disorders

DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summades of past accomplishments and the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this descdption, as is, wilt become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Specific Aims: Develop a complete pre-production MRCT system. To accomplish this goal, the specific aims are to develop the following: 1) optimized reflection target with LED back lighting; 2) electro-optics assembly; 3) optical head mechanical frame; 4) optical head enclosure; 5) system software; 6) mechanical interface to off-the-shelf manipulator; 7) calibration fixture and software. We will also evaluate performance of the system with test objects. Health Relatedness: Provide more accurate anterior surface measurements needed for research and vision intervention techniques that correct higher-order aberrations. Methods: The project incorporates a novel reflection target design, reconstruction algorithm, and a high- resolution digital camera. We refer to this new system as the muti-resolution corneal topographer (MRCT) because the reflection target employs color sinusoidal profiles that provide three simultaneous multiple- resolution ring images. Technological Innovation: The MRCT system represents a new way surface that will be more robust and accurate than other commedcally Our approach is a technological innovation over traditional reflection color sinusoidal ring target to acquire multiple-resolution ring images PERFORMANCE SITE(S) (organization, city, state) Sarver and Associates, Inc. 1020 Wild Elm Street Celebration, FL 34747 of measuring the anterior corneal available corneal topography systems. target methods in that it incorporates a (9, 17, and 33 rings) in a single exam. KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Sarver. Edwin J. Sawer and Associates, Inc. Applegate, Raymond A. University of Houston, College of Optometry Liu, David D. in the format shown below. Role on Project PI Optics consultant Ophthalmic systems and software consultant Disclosure Permission Statement. Applicable to SBIR/STTR Onlv. See instructions. [] Yes [] No PHS 398 (Rev. 05/01 ) Page 2 Number pages consecutively at the bottom throughout Form Page 2 the application. Do not usa suffixes such as 2a, 2b. Principal InvesUgatodProgram Director (Last, First, Middle): Sawer, Edwin Jay The name of the principal investigatodprogram director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT

说明：说明申请的广泛、长期目标和具体目标，并参考项目的健康相关性。描述 简要介绍了实现这些目标的研究设计和方法。避免总结过去的成就和使用第一人称。这个抽象 是为了作为一个简洁和准确的描述拟议的工作时，从申请分开。如果申请得到资助， 描述，照现在的样子，将成为公开信息。因此，不包括专有/机密信息。不要超过空间 提供了 具体目标：开发完整的预生产MRCT系统。为了实现这一目标，具体 目标是开发以下：1）优化反射目标与LED背光; 2）电光 组装; 3）光学头机械框架; 4）光学头外壳; 5）系统软件; 6）机械 与现成机械手的接口; 7）校准夹具和软件。我们还将评估绩效 的系统与测试对象。 健康相关性：提供研究和视力所需的更准确的前表面测量结果 矫正高阶像差的干预技术。 方法：该项目结合了一种新的反射目标设计，重建算法，和一个高， 分辨率数码相机我们称这种新系统为多分辨率角膜地形图仪（MRCT） 因为反射目标采用提供三个同时多个的彩色正弦曲线， 分辨率环图像。 技术创新：MRCT系统代表了一种新的方式 表面，将比其他商业更强大和准确， 我们的方法是对传统反射的技术创新 彩色正弦环形靶获取多分辨率环形图像 履约地点（组织、城市、州） Sarver and Associates，Inc. 1020 Wild Elm Street Celebration，FL 34747 测量前角膜 角膜地形图系统。 目标方法，因为它结合了 （9、17和33环）。 关键人员。参见说明。根据需要使用续页提供所需信息 从首席研究员开始。按字母顺序列出所有其他关键人员，姓在前。 名称机构 萨弗Edwin J. Sawer and Associates，Inc. 作者：Raymond A.休斯顿大学 验光 Liu，大卫D. 格式如下。 项目角色 Pi 光学顾问 眼科系统和 软件顾问 披露许可声明。仅适用于SBIR/STTR。参见说明。[]是[]否 PHS 398（版本05/01）第2页在整个表格第2页的底部连续编号 应用程序.不要使用后缀，如2a，2b。 主要投资Ugatod项目总监（最后，第一，中间）：Sawer，Edwin Jay 必须在每一打印页和每一续页的顶部提供主要赞助商和项目负责人的姓名。 研究资助