Scanning Ocular Aberration Measurement (SAM) System

扫描眼像差测量 (SAM) 系统

• 批准号: 7221219
• 负责人: Edwin Jay Sarver
• 金额: $ 27.94万
• 依托单位: SARVER AND ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221219
• 关键词: Address; Area; Arts; Caliber; Calibration; Caring; Clinical; Code; Computer software; Computers; Condition; Contact Lenses; Cornea; Corneal Topography; Coupled; Crystalline Lens; Custom; Data; Depth; Distant; Eye; Funding; Goals; Health; Intervention; Keratoconus; Laboratories; Laser Surgery; Libraries; Lighting; Location; Marketing; Measurement; Measures; Methods; Monitor; Numbers; Operative Surgical Procedures; Patients; Penetrating Keratoplasty; Penetration; Phase; Pupil; Range; Refractive Errors; Resolution; Sampling; Scanning; Severities; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Steam; Stimulus; Structure; Surface; System; Technology; Testing; Transplantation; Vision; base; commercial application; cost; cost effective; density; design; improved; instrument; lens; restoration; sensor; size; software development; software systems; technological innovation; therapy design; visual optics

DESCRIPTION (provided by applicant): 1. Project summary: The broad, long-term objective is to develop a Scanning ocular Aberration Measurement (SAM) system that solves five shortcomings of current wavefront sensors. Most or all current systems: 1) are too expensive for deep market penetration, 2) do not monitor the pupil size and location as a function of illumination and accommodation, 3) are not designed to change the accommodative demand dynamically as exams are acquired, 4) do not allow spatial sampling density to be adjusted as required depending upon the severity of the aberration structure being measured, and 5) fit the wavefront aberration with a Zernike polynomial without evaluating the impact of the resulting smoothing error and do not provide an alternative fitting method. To achieve the goal of meeting these 5 shortcomings, the specific aims for Phase II will be to: develop the SAM hardware, develop the SAM system software, develop the SAM system calibration and test items, and integrate these SAM components and perform a system level test. The commercial applications for the SAM system include clinical measurements to support custom vision correction interventions such as cornea laser surgery, custom contact lens, and custom implantable lenses. The instrument will also be able to provide an extended range of measurements for clinically difficult cases such as keratoconus or cornea transplants. Health relatedness is achieved in that a cost effective instrument with improved utility capable of handling a broader range of patients quickens the transfer of proven laboratory technology to clinical care. Technological innovations include a variable spatial sampling dependent on need by scanning a micro-lenslet array and its micro-aperture array, a see-through design, and pupil location monitoring as a function of ambient illumination and accommodation. 2. Relevance: The SAM system will provide a cost effective instrument capable of measuring a broader range of patient's ocular aberrations than is currently available. In addition, the ability to measure these aberrations dynamically while the eye is changing focus from a distant to a near object will be provided.

描述（由申请人提供）：1。项目概要：广泛的，长期的目标是开发一种扫描眼像差测量（SAM）系统，解决当前波前传感器的五个缺点。大多数或所有现有系统：1）对于深入的市场渗透来说太昂贵，2）不监视作为照明和调节的函数的瞳孔大小和位置，3）不被设计为在获取检查时动态地改变成像需求，4）不允许根据所测量的像差结构的严重性按需要调整空间采样密度，以及5）用Zernike多项式拟合波前像差，而不评估所产生的平滑误差的影响，并且不提供替代的拟合方法。为了实现解决这5个缺点的目标，第二阶段的具体目标是：开发SAM硬件、开发SAM系统软件、开发SAM系统校准和测试项目、集成这些SAM组件并进行系统级测试。SAM系统的商业应用包括支持定制视力矫正干预的临床测量，例如角膜激光手术、定制接触透镜和定制植入式透镜。该仪器还将能够为圆锥角膜或角膜移植等临床困难病例提供更大范围的测量。健康相关性的实现是因为具有改进效用的具有成本效益的仪器能够处理更广泛的患者，从而加快了经验证的实验室技术向临床护理的转移。技术创新包括根据需要通过扫描微透镜阵列及其微孔径阵列进行可变空间采样、透视设计以及根据环境照明和调节进行瞳孔位置监测。 2.相关性：SAM系统将提供一种具有成本效益的仪器，能够测量比目前可用的更宽范围的患者眼像差。此外，还将提供在眼睛将焦点从远处物体改变到近处物体时动态测量这些像差的能力。