Laboratory mouse identification and inventory control

实验室小鼠识别和库存控制

• 批准号: 7109963
• 负责人: David T. BURKE
• 金额: $ 10万
• 依托单位: MUSE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2007-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7109963
• 关键词: Mus musculus; animal colony; biomedical resource; ear; health; hospitals; housing; laboratory mouse; model; reading; tissues

DESCRIPTION (provided by applicant): Project Summary: The laboratory mouse is an essential experimental resource for modern biomedical research. Scientists currently use hundreds of varieties and strains of mice, and generate over 10 million individual animals each year. Tens of millions of dollars of NIH funding annually support mouse model research, with millions directly allocated to the maintenance of animal colonies. Mouse identification and inventory control systems have not advanced to meet the existing demand. As a result, mice are often used inefficiently, with excess animals purchased, bred, and maintained. Of equal importance, undocumented, lost, or incorrectly identified animals can compromise valuable experiments. The proposed work will produce a low-cost, integrated inventory system for the continuous monitoring of individual research mice. Existing inventory control systems in retail stores, hospitals, and shipping firms readily track individual units in complex, dynamic environments. Consequently, an extensive engineering infrastructure for inventory system development is commercially available. The proposed system will address the requirements of mouse housing facilities, animal-handling staff, veterinarians, and research investigators. The system has 3 components: (1) machine-readable labels for individual animals that are permanent and inexpensive; (2) automated readers that are compatible with the animal handling environment and have low error rates; and (3) an inventory database and query structure compatible with animal facilities and research investigators. To demonstrate the feasibility of the system, the Phase I STTR will develop and test engineering solutions for components (1) and (2). Radio-and optical-detection ear tags and tail tags will be designed, constructed, and tested. Initial testing will use models of ear and tail tissue, followed by in vivo testing for long-term compatibility and stability. In parallel, tag readers will be built and tested. For both components, specific parameters are defined in consultation with the potential users. Relevance to public health: Laboratory animals serve as critical models of human health and disease in NIH research. The quality and efficient management of animal research influences programs across many NIH Institutes and Centers. Improvements in animal inventory are essential for the control and refinement of mouse research costs, as well as minimizing the number of animals that are produced and maintained.

描述(申请人提供)：项目摘要：实验室小鼠是现代生物医学研究必不可少的实验资源。科学家目前使用数百种和品系的老鼠，每年产生超过1000万只动物。美国国立卫生研究院每年有数千万美元的资金支持老鼠模型研究，其中数百万美元直接分配给动物群体的维护。鼠标识别和库存控制系统还没有先进，无法满足现有的需求。因此，老鼠的使用效率往往很低，购买、饲养和养护的动物数量过多。同样重要的是，没有记录、丢失或识别错误的动物可能会危及有价值的实验。拟议的工作将产生一个低成本的综合库存系统，用于对单个研究小鼠的持续监测。零售店、医院和航运公司的现有库存控制系统很容易在复杂、动态的环境中跟踪单个单元。因此，库存系统开发的广泛工程基础设施在商业上是可用的。拟议的系统将满足老鼠窝设施、动物处理人员、兽医和研究调查人员的要求。该系统有3个组成部分：(1)机器可读的单个动物标签，这些标签是永久性的和廉价的；(2)与动物处理环境兼容并具有低错误率的自动阅读器；(3)与动物设施和研究人员兼容的库存数据库和查询结构。为了证明该系统的可行性，第一阶段STTR将为部件(1)和(2)开发和测试工程解决方案。无线电和光学探测耳标和尾标将被设计、建造和测试。最初的测试将使用耳朵和尾巴组织的模型，然后是体内测试，以确保长期的兼容性和稳定性。同时，还将构建和测试标签阅读器。对于这两个组件，具体参数是在与潜在用户协商后定义的。与公共卫生的相关性：在美国国立卫生研究院的研究中，实验动物是人类健康和疾病的重要模型。动物研究的质量和有效管理影响着许多NIH研究所和中心的项目。动物库存的改善对于控制和完善老鼠研究成本以及最大限度地减少生产和饲养的动物数量至关重要。