Laboratory Mouse Identification and Inventory Control
实验室小鼠识别和库存控制
基本信息
- 批准号:7628583
- 负责人:
- 金额:$ 37.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-15 至 2010-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAlprostadilAnimal ExperimentationAnimal TestingAnimalsArchitectureBiomedical ResearchBreedingComplexComputer softwareCost SavingsDataDatabasesDevelopmentDevicesDiseaseEarEngineeringEnvironmentEquipment and supply inventoriesExtramural ActivitiesFailureFrequenciesHealthHealthcareHospitalsHouse miceHousingHumanIndividualInstitutesInstitutionLabelLaboratory AnimalsLaboratory miceMaintenanceManualsManufactured MaterialsModelingMonitorMouse StrainsMusPerformancePhaseProductionRadioReaderReadingReproducibilityResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesShippingShipsSignal TransductionSimulateSmall Business Technology Transfer ResearchSterilization for infection controlStructureSystemTestingUnited States National Institutes of HealthVeterinariansWorkanimal breedinganimal facilitybasecostdata structuredatabase structuredesignergonomicsgraphical user interfacemeetingsnew technologyprogramsprototypepublic health relevanceresearch studyresponsesimulationsoftware systemssystem architecturetool
项目摘要
DESCRIPTION (provided by applicant): The laboratory mouse is an essential experimental resource for modern biomedical research. The National Institutes of Health supports intramural and extramural research on hundreds of strains of mice and millions of individual animals each year. The cost of mouse breeding and maintenance is a major component of many research programs and surpasses $40 million annually. Consequently, improvements in the efficiency of maintaining research mice are especially valuable to NIH, since they can provide recurring cost savings across many individual research efforts. Mouse identification and inventory control systems have not advanced to meet the existing demand. As a result, mice are often used inefficiently, with excess animals purchased, bred, housed, and treated unnecessarily. Of equal importance, undocumented, lost, or incorrectly identified animals can compromise valuable experiments. The Phase II STTR proposed work will produce a low-cost, integrated inventory system for the continuous, automated monitoring of individual research mice. Existing inventory control systems in retail stores, hospitals, and shipping firms readily track individual units in complex, dynamic environments. Consequently, an extensive engineering infrastructure for inventory system are readily available. The project will adapt components of existing inventory systems and develop novel technologies to the unique challenges of mouse identification, inventory, and maintenance. Working from successful prototypes developed in the STTR Phase I, a complete commercial system will be produced that satisfies the requirements of mouse housing facilities, animal-handling staff, veterinarians, and research investigators. The Specific Aims detail the four primary engineering components to be developed for the system: (1) permanent, inexpensive radio-frequency identification labels for individual animals; (2) radio-frequency automated readers that are compatible with animal handling environments; (3) tools for the rapid and humane attachment of labels onto individual mice; and (4) an inventory database and query structure compatible with the needs of animal facilities, veterinarians, and research investigators. The components will be developed in the context of both modeled and actual mouse handling environments, allowing rapid prototyping and trouble-shooting. The complete, integrated system will be extensively tested in locally- available mouse room facilities. Following testing, the inventory control system will be manufactured and sold to animal breeding and housing facilities, as well as to individual scientific research groups. PUBLIC HEALTH RELEVANCE: Laboratory animals serve as critical models of human health and disease in NIH research. The quality and efficient management of animal research influences programs across many NIH Institutes and Centers. Improvements in animal inventory are essential for the control and refinement of mouse research costs, as well as minimizing the number of animals that are produced and maintained.
描述(申请人提供):实验室小鼠是现代生物医学研究必不可少的实验资源。美国国立卫生研究院每年支持对数百种品系的老鼠和数百万只动物进行的校内和校外研究。老鼠饲养和维护的成本是许多研究项目的主要组成部分,每年超过4000万美元。因此,提高研究小鼠的维护效率对NIH特别有价值,因为它们可以在许多单独的研究工作中提供经常性的成本节约。鼠标识别和库存控制系统还没有先进,无法满足现有的需求。因此,老鼠的使用效率往往很低,购买、饲养、饲养和治疗过多的动物是不必要的。同样重要的是,没有记录、丢失或识别错误的动物可能会危及有价值的实验。拟议的第二阶段STTR工作将产生一个低成本的综合库存系统,用于对单个研究小鼠进行持续、自动化的监测。零售店、医院和航运公司的现有库存控制系统很容易在复杂、动态的环境中跟踪单个单元。因此,库存系统的广泛工程基础设施是现成的。该项目将调整现有库存系统的组件,并开发新技术,以应对鼠标识别、库存和维护方面的独特挑战。从第一阶段开发的成功原型开始,将生产出一个完整的商业系统,满足老鼠收容所、动物处理人员、兽医和研究人员的要求。具体目标详细说明了将为该系统开发的四个主要工程组件:(1)针对单个动物的永久、廉价的射频识别标签;(2)与动物处理环境兼容的射频自动阅读器;(3)快速、人道地将标签贴在单个老鼠身上的工具;以及(4)符合动物设施、兽医和研究人员需求的库存数据库和查询结构。这些组件将在建模和实际鼠标操作环境的背景下开发,从而实现快速原型制作和故障排除。完整、集成的系统将在当地可用的鼠房设施中进行广泛测试。在测试之后,库存控制系统将被制造并出售给动物饲养和饲养设施,以及个别科研小组。公共卫生相关性:在美国国立卫生研究院的研究中,实验动物是人类健康和疾病的重要模型。动物研究的质量和有效管理影响着许多NIH研究所和中心的项目。动物库存的改善对于控制和完善老鼠研究成本以及最大限度地减少生产和饲养的动物数量至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David T. BURKE其他文献
David T. BURKE的其他文献
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{{ truncateString('David T. BURKE', 18)}}的其他基金
Laboratory Mouse Identification and Inventory Control
实验室小鼠识别和库存控制
- 批准号:
7479537 - 财政年份:2006
- 资助金额:
$ 37.5万 - 项目类别:
Laboratory mouse identification and inventory control
实验室小鼠识别和库存控制
- 批准号:
7109963 - 财政年份:2006
- 资助金额:
$ 37.5万 - 项目类别:
INTEGRATED DNA GENOTYPING AND SEQUENCING MICROSYSTEMS
集成 DNA 基因分型和测序微系统
- 批准号:
6583200 - 财政年份:2001
- 资助金额:
$ 37.5万 - 项目类别:
CORE--FABRICATION, ASSEMBLY, AND TESTING SUPPORT
核心——制造、组装和测试支持
- 批准号:
6583199 - 财政年份:2001
- 资助金额:
$ 37.5万 - 项目类别:
INTEGRATED DNA GENOTYPING AND SEQUENCING MICROSYSTEMS
集成 DNA 基因分型和测序微系统
- 批准号:
6442987 - 财政年份:2001
- 资助金额:
$ 37.5万 - 项目类别:
CORE--FABRICATION, ASSEMBLY, AND TESTING SUPPORT
核心——制造、组装和测试支持
- 批准号:
6442986 - 财政年份:2001
- 资助金额:
$ 37.5万 - 项目类别:
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