Development of multispectral imaging to measure oxygenation in skin

该项目旨在评估多光谱成像（MSI）是否可用于测量系统性硬化症（SSc）患者皮肤中的血氧含量。MSI提供了对大面积（在这种情况下是整个手）进行成像并生成氧合图像图的能力。目标是测试，改进和开发一个光学系统，并使用相关的分析软件。学生将开始评估现有的MSI系统，开发成像协议和分析软件。这将在患者和健康对照组中进行试验（与联合监督员工作的索尔福德NHS信托合作）。然后，他们将继续改进光学（硬件和软件），以提高准确性和再现性，目的是开发一种可用于帮助监测SSc进展的系统。将对光在组织中的传输、散射和吸收进行建模，并将这些模型进行比较，以确定哪种模型提供最准确和可靠的计算氧合的方法。该项目包括光学硬件、组织光学（光子传输）、成像、软件和详细的数据分析等方面。

The project aims to assess whether multispectral imaging (MSI) can be used to measure blood oxygenation in the skin of patients with systemic sclerosis (SSc). MSI offers the ability to image large areas (whole hands in this case) and produce an image map of oxygenation. The objectives are to test, improve and develop an optical system to do this, with associated analysis software. The student will start by assessing an existing MSI system, developing an imaging protocol and software for analysis. This will be trialed with patients and healthy controls (collaborating with the Salford NHS trust where the co-supervisor works). They will then move on to improving the optics (hardware and software) to achieve increased accuracy and reproducibility, with the aim of developing a system that can be used to help monitor the progression of SSc. The transmission, scattering, and absorption of light in tissue will be modelled and these models will be compared to see which provide the most accurate and reliable method of calculating oxygenation.The project contains aspects of optics hardware, tissue optics (photon transport), imaging, software and detailed data analysis.