A time, spatial and phase domain gated multispectral imaging for diagnostics and therapy monitoring

用于诊断和治疗监测的时间、空间和相域门控多光谱成像

• 批准号: RGPIN-2017-06462
• 负责人: Douplik, Alexandre
• 金额: $ 1.53万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762446
• 关键词: time; spatial; phase; domain; gated

A time, spatial and phase domain gated multispectral imaging for diagnostics and therapy monitoringThe applicant's research program is in the area of biophotonics, where light is employed for diagnostics and therapy. The advantage of optical diagnostics is minimally or noninvasive interaction while providing important information about structural, metabolic and molecular changes in biotissues. Usage of light therapy and surgery minimizes destruction of non-targeted tissues and does not involve interaction with ionizing radiation. Altogether, biophotonics proposes advanced and in some cases unique solutions for patient care. The applicant's research program is focused on imaging diagnostics, treatment feedback and monitoring. The proposed research strategy concentrates on superficial and endoscopic applications, exploiting multispectral time, spatial and phase gated imaging technologies where each pixel of the image provides information about tissue morphology and metabolism via interpretation of absorption, scattering, refraction index, fluorescence and Raman properties. The proposed research can be conditionally divided into 3 directions: (1) combined fluorescence and Raman microendoscopy for interstitial optical biopsy (currently the main application is the breast surgery); (2) spatial gated imaging for deep interrogation of highly scattering media (currently the main application is skin micro-circulation morphology); (3) a large field of view multi-spectral time domain holographic interferometry imaging (currently the main applications are instant monitoring of antibiotic-bacterial reactions and photodynamic reactions in vitro). During the last 5 years since I applied to my first Discovery:A number of new research modalities were developed and invented in my group, 3 my PhD students and 2 Master students have already finished, 1 my postdoc has become CEO and President of the company Oxilight at Ryerson Biomedzone with current level of investments and funding more than 200K, 1 of my PhD students accepted the position of Assistant Professor in Zurich University, and currently my group includes 3 PhDs, 5 Master students and 4 undegrad research assistants. I have published with my students and postoc 27 peer-reviewed publications, 6 book chapters, 20 proceedings, filed and submitted 4 patent applications. I obtained 5 appointments as a visiting professor (Technical University of Munich, Germany, University Erlangen-Nuremberg, Germany; University of Montpellier, France; Kagoshima University, Japan; University of Aveiro, Portugal), guest edited 1 journal issue (Photomedicine), accepted 1 invitation into Editorial Board (Biomedical Photonics) , conducted 15 key-note and invited lectures in Canada, USA, Germany, France, Japan, Israel, Ukraine, Russia, Portugal, chairing 4 conferences and participated in 5 conference program committees.

用于诊断和治疗监测的时间，空间和相位域门控多光谱成像申请人的研究项目属于生物光子学领域，其中光被用于诊断和治疗。光学诊断的优点是在提供生物组织结构、代谢和分子变化的重要信息的同时，进行微创或非侵入性的相互作用。使用光疗和手术可以最大限度地减少对非靶组织的破坏，并且不涉及与电离辐射的相互作用。总之，生物光子学为病人护理提供了先进的，在某些情况下是独特的解决方案。申请人的研究方向是影像诊断、治疗反馈和监测。提出的研究策略集中于表面和内窥镜应用，利用多光谱时间、空间和相位门控成像技术，其中图像的每个像素通过解释吸收、散射、折射率、荧光和拉曼特性提供有关组织形态和代谢的信息。拟开展的研究可有条件地分为3个方向：(1)荧光与拉曼显微内镜联合进行间质光学活检（目前主要应用于乳腺外科）；(2)用于高散射介质深度探测的空间门控成像（目前主要应用于皮肤微循环形态学）；(3)大视场多光谱时域全息干涉成像（目前主要应用于抗生素-细菌反应和体外光动力反应的即时监测）。在过去5年以来我第一次应用于发现:许多新的研究模式开发和发明在我组,3我的博士生和2硕士学生已经完成,1我的博士后已经成为该公司的首席执行官和总裁在瑞尔森Biomedzone Oxilight目前的投资水平和资金超过200 k, 1我的博士生接受苏黎世大学助理教授的职位,目前我组包括3个博士学位,硕士生5人，本科生助教4人。我和我的学生一起发表了27篇同行评审的出版物，6本书章节，20篇论文，提交并提交了4项专利申请。曾获5次访问教授（德国慕尼黑工业大学、德国埃尔朗根-纽伦堡大学、法国蒙彼利埃大学、日本鹿儿岛大学、德国慕尼黑工业大学、德国埃尔朗根-纽伦堡大学、法国蒙彼利埃大学、日本鹿儿岛大学、德国蒙彼利埃大学）。葡萄牙阿威罗大学)，客座编辑期刊（Photomedicine） 1期，接受编辑委员会（Biomedical Photonics）邀请1次，在加拿大、美国、德国、法国、日本、以色列、乌克兰、俄罗斯、葡萄牙等地进行主题演讲和特邀演讲15次，主持会议4次，参加会议计划委员会5次。