Integrated Maglev Pump-Oxygenator for Respiratory Support

用于呼吸支持的集成磁悬浮泵氧合器

• 批准号: 7108046
• 负责人: KURT A DASSE
• 金额: $ 26.7万
• 依托单位: THORATEC, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108046
• 关键词: artificial membranes; biomaterial compatibility; biomedical equipment development; blood circulation; blood oxygenator; blood volume; clinical biomedical equipment; computer simulation; hemodynamics; magnetism; nonhuman therapy evaluation; respiratory gas transport; respiratory therapy; sheep

DESCRIPTION (provided by applicant): The death rate due to respiratory disease has increased nearly 20% in the United States since 1979, surpassing virtually all other types of disease. Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30 and 70%. Current treatment is limited to extracorporeal membrane oxygenation (ECMO), but ECMO systems are generally assembled from multiple, unmatched components to create a pump-oxygenator circuit. These circuits result in higher than desired priming volume and membrane surface area because of non-optimized blood flow dynamics. In order to overcome these limitations, we have proposed the development of a novel artificial respiratory device capable of sustained respiratory support. The goal of this proposal is to develop an integrated pump-oxygenator (IPO) device, which incorporates durable membranes and magnetically levitated blood pump technology to produce a highly efficient respiratory support system with low priming volumes. Accordingly, our specific aims include the following: Specific Aim 1: Employ fluid simulation methods to model blood pumping function, gas transfer and hemocompatibility, and use these results to design and fabricate oxygenator components with optimal size and operating parameters. Specific Aim 2: Fabricate the components of the IPO prototype device for in-vitro characterization, including an evaluation of device blood flow performance. Specific Aim 3: Evaluate the device in-vitro utilizing bovine blood to assess gas exchange and the effects on blood. Specific Aim 4: Conduct in-vivo animal studies (3) in sheep to assess in-vivo hemodynamics, gas exchange and biocompatibility of the IPO device. Successful completion of this project will result in the development of a portable pump oxygenator system characterized by improved hemocompatibility, due to the use of the MagLev pump, improved oxygen efficiency, due to enhanced blood recirculation and blood flow dynamics, and ease of manufacturing, due to its modular design. We anticipate that such as system will be capable of providing long term respiratory support (weeks to months). The availably of such a device should have significant impact on reducing mortality due to severe, acute respiratory disorders.

描述（由申请人提供）：自1979年以来，美国呼吸系统疾病的死亡率增加了近20%，几乎超过了所有其他类型的疾病。仅成人呼吸窘迫综合征（ARDS）每年就折磨着大约15万名患者，死亡率在30%至70%之间。目前的治疗仅限于体外膜氧合（ECMO），但ECMO系统通常由多个不匹配的组件组装而成，以创建泵-氧合器回路。由于血流动力学未优化，这些回路导致预充体积和膜表面积高于预期。为了克服这些局限性，我们提出了一种新型的人工呼吸装置的持续呼吸支持能力的发展。本提案的目标是开发一种集成泵-氧合器（IPO）器械，该器械采用耐用膜和磁悬浮血泵技术，以生产具有低预充量的高效呼吸支持系统。因此，我们的具体目标包括以下内容：具体目标1：采用流体模拟方法对血液泵送功能、气体传输和血液相容性进行建模，并使用这些结果设计和制造具有最佳尺寸和操作参数的氧合器组件。具体目标二：制造IPO原型器械的组件，用于体外表征，包括器械血流性能评价。具体目标3：使用牛血在体外评价器械，以评估气体交换和对血液的影响。具体目标4：在绵羊中进行体内动物研究（3），以评估IPO器械的体内血流动力学、气体交换和生物相容性。该项目的成功完成将导致便携式泵氧合器系统的开发，其特征在于由于使用MagLev泵而改善了血液相容性，由于增强了血液再循环和血流动力学而改善了氧效率，并且由于其模块化设计而易于制造。我们预计，这种系统将能够提供长期的呼吸支持（数周至数月）。这种设备的可用性应该对降低严重急性呼吸系统疾病的死亡率具有显著影响。

项目成果

Functional and biocompatibility performances of an integrated Maglev pump-oxygenator.

集成磁悬浮泵氧合器的功能和生物相容性性能。

• DOI: 10.1111/j.1525-1594.2008.00672.x
• 发表时间: 2009
• 期刊: Artificial organs
• 影响因子: 2.4
• 作者: Zhang,Tao;Cheng,Guangming;Koert,Andrew;Zhang,Juntao;Gellman,Barry;Yankey,GKwame;Satpute,Aditee;Dasse,KurtA;Gilbert,RichardJ;Griffith,BartleyP;Wu,ZhongjunJ
• 通讯作者: Wu,ZhongjunJ