GENETICALLY MODIFIED RHESUS MONKEYS

转基因恒河猴

• 批准号: 7348901
• 负责人: DON P WOLF
• 金额: $ 15.35万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7348901
• 关键词: GENETICALLY; MODIFIED; RHESUS; MONKEYS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal is to produce genetically-modified rhesus monkeys that will serve as models for human neurogenetic diseases. Our working hypothesis is that gene targeting and somatic cell cloning technology can, in combination, provide the basis for generating a reliable supply of animals that accurately represent human disease. We will focus on three, early-onset, loss-of-function conditions: Kallmann's syndrome, Lesch-Nyhan's disease and Ataxia-Telangiectasia.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。长期目标是培育转基因恒河猴，作为人类神经遗传疾病的模型。我们的工作假设是，基因靶向和体细胞克隆技术相结合，可以为产生可靠的动物供应提供基础，准确地代表人类疾病。我们将重点关注三种早发性功能丧失疾病：Kallmann综合征、Lesch-Nyhan病和共济失调性毛细血管扩张症。