GENETICALLY MODIFIED RHESUS MONKEYS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。长期目标是培育出转基因恒河猴，作为人类神经遗传性疾病的模型。我们的工作假设是，基因打靶和体细胞克隆技术相结合，可以为产生准确代表人类疾病的可靠动物供应提供基础。我们将集中于三种早发性、功能丧失的情况：卡尔曼综合征、莱施-尼汉氏病和共济失调-毛细血管扩张症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal is to produce genetically-modified rhesus monkeys that will serve as models for human neurogenetic diseases. Our working hypothesis is that gene targeting and somatic cell cloning technology can, in combination, provide the basis for generating a reliable supply of animals that accurately represent human disease. We will focus on three, early-onset, loss-of-function conditions: Kallmann's syndrome, Lesch-Nyhan's disease and Ataxia-Telangiectasia.