GENETICALLY MODIFIED RHESUS MONKEYS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal is to produce genetically-modified rhesus monkeys that will serve as models for human neurogenetic diseases. Our working hypothesis is that gene targeting and somatic cell cloning technology can, in combination, provide the basis for generating a reliable supply of animals that accurately represent human disease. We will focus on three, early-onset, loss-of-function conditions: Kallmann's syndrome, Lesch-Nyhan's disease and Ataxia-Telangiectasia.