SUPPRESSION OF BREAKTHROUGH BLEEDING IN USERS OF PROGESTIN CONTRACEPTIVES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。释放左炔诺孕酮（LNG）的植入物（例如，Norplant）和释放LNG的宫内节育器（LNG-IUS;例如，曼月乐IUS）是非常有效的避孕方法的妇女。然而，使用这些方法的妇女经常经历突破性子宫出血，这往往导致她们停止这种形式的避孕。恒河猴在用LNG-IUS治疗时也显示出突破性出血，并且可以为评估控制出血的新疗法提供有用的动物模型。我们的研究目标是利用恒河猴进一步表征LNG-IUS对子宫内膜的影响，并测试间歇性孕酮拮抗剂治疗LNG-IUS使用引发的子宫出血。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG) releasing implants (e.g., Norplant), and LNG -releasing intrauterine devices (LNG-IUS; e.g., Mirena IUS) are very effective methods of contraception for women. However, women using these methods frequently experience breakthrough uterine bleeding that often leads them to discontinue this form of contraception. Rhesus macaques also display breakthrough bleeding when treated with LNG-IUS, and can provide a useful animal model for assessing novel therapies to control the bleeding. Our goal in research is to utilize rhesus macaques to further characterize the effect of LNG-IUS on the endometrium, and to test intermittent progesterone antagonist therapy as a treatment for uterine bleeding triggered by LNG-IUS use.