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Effects of HIV & HAART on Sleep & Daytime Function

艾滋病毒的影响

基本信息

批准号：
7267813
负责人：
PHILIP L SMITH
金额：
$ 56.8万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7267813
关键词：
AIDS Dementia Complex Accounting Age Anti-Retroviral Agents Baltimore Behavioral Cellular Immunity Central obesity Cessation of life Chronic Cognitive Cohort Studies Comorbidity Condition Data Dementia Depressed mood Development Disease Disruption Drowsiness Elevation Fatigue Fatty acid glycerol esters Functional disorder Gays Gender HIV HIV Infections HIV Protease Inhibitors Highly Active Antiretroviral Therapy Humoral Immunities Hypoxia Incidence Individual Infection Interleukin-6 Lead Leptin Life Life Expectancy Link Lipodystrophy Longevity Longitudinal Studies Measures Mechanics Medical Methods Molecular Morbidity - disease rate Motor Mus Neurocognitive Obesity Obstructive Sleep Apnea Opportunistic Infections Other Genetics Pathogenesis Pathway interactions Patients Performance Plague Predisposition Prevalence Protease Inhibitor Proteins Quality of life Research Personnel Risk Factors Sensory Receptors Series Severities Signaling Protein Site Sleep Sleep Apnea Syndromes Sleep Architecture Sleep disturbances Societies Source Structure Symptoms Treatment Protocols Ventilatory Depression Wakefulness airway obstruction cohort cytokine immune function improved leptin receptor male men mouse model neurobehavioral neuromechanism novel prevent programs respiratory

项目摘要

DESCRIPTION (provided by applicant): HIV is recognized as a devastating infection that leads to severe morbidity and earlier death. It is known that HIV infection is associated not only with disruptions in immune function but also in sleep with daytime fatigue, somnolence and impaired quality of life. Highly Active Anti-Retroviral Therapy (HAART) is now extending the life expectancy of those infected with HIV either allowing or producing chronic medical conditions and significant associated medical comorbidity. Our preliminary data indicate that both HIV infection and HAART are associated with substantial daytime fatigue. Moreover, HAART is also associated with sleep apnea, a known cause of sleep disruption and daytime somnolence. Our major hypothesis is that HIV infection, HAART, and associated alterations in humoral factors and cellular immunity lead to sleep disruption and sleep apnea, which both cause daytime dysfunction. In Specific Aim 1, we will elucidate the effects of HIV and HAART on nocturnal sleep architecture and daytime function. We hypothesize that HIV infection will be associated with sleep disruption and alterations in measures of daytime sleepiness, neurocognitive and neurobehavioral function, and quality of life. In Specific Aim 2, we will delineate the effects of HIV and HAART on the severity of upper airway obstruction and sleep. We hypothesize that HAART, but not HIV infection, is associated with an increased susceptibility for sleep apnea due to alterations in regional fat distribution and leptin. In Specific Aim 3, we will elucidate specific humoral and molecular pathways involved in the pathogenesis of upper airway, ventilatory and sleep/wake dysregulation. In this proposal, we capitalize on the well-established Baltimore site or the Multicenter Aids Cohort Study (MACS), a longitudinal study of HIV infection in gay men, to determine the impact of these factors on sleep quality, sleep apnea and daytime function. In a series of complementary murine studies, we further probe causal pathways involved in the pathogenesis of upper airway, respiratory and sleep/wake dysfunction. Conventional methods will be employed to assess sleep architecture, cellular immunity, humoral factors and daytime function, while novel analytic approaches will be used to quantify effects of HIV infection and therapy on sleep structure and upper airway function.

描述（由申请人提供）：