STUDY OF IMMUNE EFFECTS ON SLEEP AND (HIV) TREATMENT ON APNEA (SIESTA)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。众所周知，艾滋病毒本身与睡眠中断有关，导致白天疲劳、嗜睡和生活质量受损。HAART疗法可以延长寿命，但会导致代谢紊乱，容易导致睡眠呼吸暂停。本研究的主要假设是HIV感染、HAART以及体液因子和细胞免疫的相关改变导致睡眠中断和睡眠呼吸暂停，这两者都会导致白天功能障碍。为了解决这一假设，提出了两个具体目标。1)阐明HIV和HAART对夜间睡眠结构和日间功能的影响。2)描述HIV和HAART对上呼吸道阻塞严重程度和睡眠的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is know that HIV itself is associated with disruptions in sleep with resultant daytime fatigue, somnolence, and impaired quality of life. HAART therapy is extending life but leading to metabolic derangements that predispose to sleep apnea. The major hypothesis of this study is that HIV infection, HAART, and associated alterations in humoral factors and cellular immunity lead to sleep disruption and sleep apnea which both cause daytime dysfunction. To address this hypothesis, two specific aims are proposed. 1) Elucidate the effects of HIV and HAART on nocturnal sleep architecture and daytime function. 2) Delineate the effects of HIV and HAART on the severity of upper airway obstruction and sleep.