STUDY OF IMMUNE EFFECTS ON SLEEP AND (HIV) TREATMENT ON APNEA (SIESTA)

免疫对睡眠的影响和（HIV）治疗呼吸暂停（午睡）的研究

• 批准号: 7375845
• 负责人: PHILIP L SMITH
• 金额: $ 3.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375845
• 关键词: STUDY; IMMUNE; EFFECTS; SLEEP; HIV

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is know that HIV itself is associated with disruptions in sleep with resultant daytime fatigue, somnolence, and impaired quality of life. HAART therapy is extending life but leading to metabolic derangements that predispose to sleep apnea. The major hypothesis of this study is that HIV infection, HAART, and associated alterations in humoral factors and cellular immunity lead to sleep disruption and sleep apnea which both cause daytime dysfunction. To address this hypothesis, two specific aims are proposed. 1) Elucidate the effects of HIV and HAART on nocturnal sleep architecture and daytime function. 2) Delineate the effects of HIV and HAART on the severity of upper airway obstruction and sleep.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。众所周知，艾滋病毒本身与睡眠中断有关，从而导致白天疲劳、嗜睡和生活质量受损。 HAART 疗法可以延长寿命，但会导致代谢紊乱，从而导致睡眠呼吸暂停。这项研究的主要假设是，HIV 感染、HAART 以及相关的体液因子和细胞免疫的改变会导致睡眠中断和睡眠呼吸暂停，从而导致日间功能障碍。为了解决这一假设，提出了两个具体目标。 1) 阐明 HIV 和 HAART 对夜间睡眠结构和日间功能的影响。 2) 描述HIV和HAART对上呼吸道阻塞和睡眠严重程度的影响。