STUDY OF IMMUNE EFFECTS ON SLEEP AND (HIV) TREATMENT ON APNEA (SIESTA)

免疫对睡眠的影响和（HIV）治疗对呼吸暂停（午睡）的研究

• 批准号: 7607488
• 负责人: PHILIP L SMITH
• 金额: $ 7.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607488
• 关键词: Address; Apnea; Cellular Immunity; Computer Retrieval of Information on Scientific Projects Database; Disruption; Drowsiness; Fatigue; Functional disorder; Funding; Grant; HIV; HIV Infections; Highly Active Antiretroviral Therapy; Immune; Institution; Lead; Life; Metabolic; Quality of life; Research; Research Personnel; Resources; Severities; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Source; United States National Institutes of Health; airway obstruction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is know that HIV itself is associated with disruptions in sleep with resultant daytime fatigue, somnolence, and impaired quality of life. HAART therapy is extending life but leading to metabolic derangements that predispose to sleep apnea. The major hypothesis of this study is that HIV infection, HAART, and associated alterations in humoral factors and cellular immunity lead to sleep disruption and sleep apnea which both cause daytime dysfunction. To address this hypothesis, two specific aims are proposed. 1) Elucidate the effects of HIV and HAART on nocturnal sleep architecture and daytime function. 2) Delineate the effects of HIV and HAART on the severity of upper airway obstruction and sleep.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 众所周知，HIV本身与睡眠中断有关，导致白天疲劳、嗜睡和生活质量受损。HAART治疗延长了生命，但导致易患睡眠呼吸暂停的代谢紊乱。本研究的主要假设是，HIV感染、HAART以及体液因子和细胞免疫的相关改变导致睡眠中断和睡眠呼吸暂停，这两者都导致日间功能障碍。 为了解决这一假设，提出了两个具体目标。1)阐明HIV和HAART对夜间睡眠结构和日间功能的影响。2)描述HIV和HAART对上呼吸道阻塞和睡眠严重程度的影响。