Re-imagining Peptide Synthesis

开发能够以比生物生产更低的成本和更高的可靠性，通过有机化学加工生产生物制药的技术。该项目将为多肽和蛋白质的合成制造创造一种全新的技术。这些将通过在液相中顺序(迭代)添加AA构建块或AA片段来创建，关键是，每个阶段的纯化将通过有机溶剂纳滤(OSN)在液体中继续进行。附着在纳米STAR大分子结构上的生长多肽将被OSN膜选择性地保留，而多余的积木和其他碎片通过膜的渗透被去除。这一新的过滤技术将使液相合成的所有好处得以实现，同时提供方便的分离。

To develop technology capable of biopharmaceutical production via organic chemical processing, at lower cost and with greater reliability than biological production.The project will create a radical new technology for the synthetic manufacture of peptides and proteins. These will be created through sequential (iterative) addition of AA building blocks or AA fragments in the liquid phase, and, crucially, purification at each stage will continue in the liquid phase by organic solvent nanofiltration (OSN). The growing peptide attached to a nanostar macromolecular construct will be selectively retained by the OSN membranes, while excess building blocks and other debris are removed by permeation through the membrane. This new filtration technology will allow all the benefits of liquid phase synthesis to accrue while providing facile separation.