Re-imagining Peptide Synthesis

重新想象肽合成

• 批准号: 2862919
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2862919
• 关键词: Re; imagining; Peptide; Synthesis

To develop technology capable of biopharmaceutical production via organic chemical processing, at lower cost and with greater reliability than biological production.The project will create a radical new technology for the synthetic manufacture of peptides and proteins. These will be created through sequential (iterative) addition of AA building blocks or AA fragments in the liquid phase, and, crucially, purification at each stage will continue in the liquid phase by organic solvent nanofiltration (OSN). The growing peptide attached to a nanostar macromolecular construct will be selectively retained by the OSN membranes, while excess building blocks and other debris are removed by permeation through the membrane. This new filtration technology will allow all the benefits of liquid phase synthesis to accrue while providing facile separation.

通过有机化学处理开发生物制药生产技术，以比生物生产更低的成本和更高的可靠性。该项目将为肽和蛋白质的合成制造创造一种全新的技术。这些将通过在液相中顺序（迭代）添加AA结构单元或AA片段来产生，并且至关重要的是，每个阶段的纯化将通过有机溶剂纳滤（OSN）在液相中继续。连接到纳米星大分子构建体的生长肽将被OSN膜选择性地保留，而过量的结构单元和其他碎片通过渗透穿过膜而被去除。这种新的过滤技术将允许液相合成的所有好处，同时提供方便的分离。