Nutritional strategies to stimulate endogenous antimicrobial peptides in poultry: A promising alternative to antibiotics with a smart solution for saf

刺激家禽内源性抗菌肽的营养策略：一种有前景的抗生素替代品，为 SAF 提供智能解决方案

• 批准号: 2868919
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2868919
• 关键词: Nutritional; strategies; stimulate; endogenous; antimicrobial

Project Description for Find-A-PhD Advert (max 400 words). This will be the text that is advertised to prospective students:Increasing antimicrobial resistance is a global concern for consumers, public health authorities, farmers and food standard agencies. Antimicrobial peptides (AMPs) are emerging as an effective non-antibiotic tool to combat infectious diseases in poultry. However, the prophylactic application of synthetic AMPs is limited due to their higher production cost and product stability issues. Nutritional manipulation to induce and regulate the expression of endogenous AMPs can be a smart solution to tackle the strategic challenge of producing sustainable, resilient and safe poultry. This PhD project aims to identify the ability of novel feed additives (B-glucan and oligosaccharides derived from yeast and cereal) to stimulate host AMPs in situ and to reveal how nutritional supplementation of feed additives can manipulate the expression of avian host AMPs in the gut under mild sub-clinical disease conditions. The main objectives of the study would be 1) Optimisation of B-glucan structure and function to maximise broiler immune and metabolic responses in antibiotic-free diets 2) Identification of the mode of action of these host AMP's in the gut in order to establish a diagnostic marker to aid in promoting consistency in the commercial application of these novel feed additives, and 3) Develop a link between the concentration and inhibitory abilities of these host AMPs against bacterial, viral and parasitic pathogens in the avian gut.The student will be registered at the University of Edinburgh and based at Monogastric Science Research Center (MSRC) of Scotland's Rural College (SRUC; near Edinburgh, UK). In vivo studies will be conducted at the SRUC's new state of art poultry research facility, which is the UK's largest facility dedicated to fostering world-leading research to benefit agricultural food safety and security, animal health and welfare, public health, and environmental impact/climate change by trialling innovative ideas under near-commercial conditions. The project will partner with AB Vista, an animal nutrition and technology company that is one of the largest feed additives suppliers globally. The student will work very closely with AB Vista, including an industrial placement of no less than 12 weeks. During placement, the student will be trained and supported by Dr Mike Bedford at AB Vista, Marlborough, UK. At this site, the student will obtain detailed practical knowledge of the sector by working with global team members with a range of expertise, including industrial production of feed additives, nutrigenomics, R&D development, manufacturing operations, financial management and communication skills (both academic and non-academic). Additionally, at SRUC and University of Edinburgh, skills training will be provided in personal effectiveness, communication skills, networking and team working, study design, molecular biology, metataxonomics (16S rRNA gene sequencing), metagenomics (whole shotgun metagenomic sequencing) and career management. This project is multidisciplinary and combines nutritional, immunology, molecular, genomic and statistical science to provide insight into the effect of novel feed additives as an alternative to antibiotics. The supervisory team brings the necessary complementary expertise in each of these fields and will support the student in developing academic skills within each discipline. The combination of on-farm training, lab skills, and exposure to world-leading companies will ensure that the student is well prepared for a career in academia or industry.SRUC and its associated partner organisations aim to create a community that is innovative, inclusive and collaborative, in which everyone feels valued, respected, and supported, and we encourage applications from a diverse range of qualified applicants.

寻找博士广告的项目描述（最多400字）。这将是向未来学生宣传的文本：增加抗菌素耐药性是消费者，公共卫生当局，农民和食品标准机构的全球关注。抗菌肽（AMP）是一种有效的非抗生素工具，以打击家禽传染病。然而，合成AMP的预防性应用由于其较高的生产成本和产品稳定性问题而受到限制。诱导和调节内源性AMP表达的营养操纵可能是应对生产可持续，有弹性和安全家禽的战略挑战的明智解决方案。该博士项目旨在确定新型饲料添加剂（B-葡聚糖和来源于酵母和谷物的寡糖）原位刺激宿主AMP的能力，并揭示饲料添加剂的营养补充如何在轻度亚临床疾病条件下操纵肠道中禽类宿主AMP的表达。本研究的主要目的是：1）优化β-葡聚糖的结构和功能，以最大限度地提高肉鸡在无磷饮食中的免疫和代谢反应; 2）鉴定这些宿主AMP在肠道中的作用模式，以建立诊断标志物，帮助促进这些新型饲料添加剂商业应用的一致性，以及3）开发这些宿主AMP的浓度和对禽肠道中细菌、病毒和寄生虫病原体的抑制能力之间的联系。该学生将在爱丁堡大学注册，并在苏格兰农村学院的单胃科学研究中心（MSRC）工作（SRUC;靠近英国爱丁堡）。体内研究将在SRUC新的最先进的家禽研究设施进行，该设施是英国最大的设施，致力于促进世界领先的研究，通过在接近商业化的条件下试验创新想法，使农业食品安全和保障，动物健康和福利，公共卫生和环境影响/气候变化受益。该项目将与全球最大的饲料添加剂供应商之一的动物营养和技术公司AB Vista合作。学生将与AB Vista密切合作，包括不少于12周的工业实习。在实习期间，学生将在英国马尔伯勒的AB Vista接受Mike贝德福德博士的培训和支持。在这个网站上，学生将通过与具有一系列专业知识的全球团队成员合作，获得该行业的详细实践知识，包括饲料添加剂的工业生产，营养基因组学，研发开发，制造运营，财务管理和沟通技巧（学术和非学术）。 此外，在SRUC和爱丁堡大学，将提供个人效能，沟通技巧，网络和团队合作，研究设计，分子生物学，元组学（16 S rRNA基因测序），宏基因组学（全鸟枪宏基因组测序）和职业管理方面的技能培训。该项目是多学科的，结合了营养学、免疫学、分子学、基因组学和统计学，以深入了解新型饲料添加剂作为抗生素替代品的效果。监督团队带来了必要的补充专业知识，在这些领域中的每一个，并将支持学生在每个学科发展的学术技能。农场培训，实验室技能和接触世界领先的公司的组合将确保学生为学术界或工业界的职业生涯做好充分准备。SRUC及其相关合作伙伴组织旨在创建一个创新，包容和协作的社区，每个人都感到受到重视，尊重和支持，我们鼓励来自各种合格申请人的申请。