Regenerative Sciences Training Program(RMI)

描述(由申请人提供)： 这项建议寻求对再生科学新的跨学科培训计划的发展的支持。组织的修复或再生可以被描述为细胞活动的交响乐，通常始于急性炎症反应，随后是肉芽组织的渗透、募集、祖细胞的增殖和分化、基质的形成和组织，以及最终的重塑。这一过程发生在生物和机械信号的背景下。虽然许多科学家、工程师和临床医生在众多学科中工作，致力于促进组织和器官的修复或再生，但他们缺乏沟通、解释或整合许多核心能力的能力，我们认为这些能力是再生医学取得实质性进展所必需的。这些核心能力包括：发育生物学、细胞外基质结构和组织、生物调节信号、组织结构和功能、临床前模型开发、结构和计算建模、临床研究设计原则以及商业化和调节参数。该计划将招收在一个或多个学科具有培训深度的生物学家、工程师和临床医生，并通过教学和研究密集的经验教授他们这些核心能力的关键方面，从而增强他们的能力。虽然这一培训计划将在未来扩大到所有器官或组织系统的培训，但其最初的培训将侧重于肌肉骨骼组织。

DESCRIPTION (provided by applicant): This proposal seeks support for the development of a new interdisciplinary training program in Regenerative Science. Repair or regeneration of tissues can be characterized as a symphony of cellular activities often beginning with an acute inflammatory response followed by granulation tissue infiltration, recruitment, proliferation and differentiation of progenitor cells, matrix formation and organization, and eventual remodeling. The process occurs within the context of biologic and mechanical signals. While many scientists, engineers and clinicians working across numerous disciplines are dedicated to advancing the repair or regeneration of tissues and organs, they fall short in their ability to communicate, interpret, or integrate across the many core competencies that we believe are required to make substantial advances in regenerative medicine. These core competencies include: developmental biology, extracellular matrix structure and organization, bioregulatory signaling, tissue structure and function, preclinical models development, structural and computational modeling, clinical research design principles, and commercialization and regulatory parameters. This program will admit biologists, engineers and clinicians with training depth in one or more disciplines and augment their abilities by teaching them critical aspects of these core competencies through didactic and research intensive experiences. While this training program will expand to train in all organ or tissue systems in the future, its initial training will focus on musculoskeletal tissues.