Regenerative Sciences Training Program(RMI)

描述（由申请人提供）： 该提案寻求支持再生科学新的跨学科培训计划的发展。组织的修复或再生可以表征为细胞活动的交响乐，通常以急性炎症反应开始，随后是肉芽组织浸润、祖细胞的募集、增殖和分化、基质形成和组织化以及最终重塑。这个过程发生在生物和机械信号的背景下。虽然许多科学家，工程师和临床医生致力于促进组织和器官的修复或再生，但他们缺乏沟通，解释或整合我们认为在再生医学方面取得实质性进展所需的许多核心能力的能力。这些核心能力包括：发育生物学、细胞外基质结构和组织、生物调节信号传导、组织结构和功能、临床前模型开发、结构和计算建模、临床研究设计原理以及商业化和调节参数。该计划将承认生物学家，工程师和临床医生在一个或多个学科的培训深度，并通过教学和研究密集的经验教他们这些核心竞争力的关键方面来增强他们的能力。虽然该培训计划将在未来扩展到所有器官或组织系统的培训，但其初始培训将集中在肌肉骨骼组织。

DESCRIPTION (provided by applicant): This proposal seeks support for the development of a new interdisciplinary training program in Regenerative Science. Repair or regeneration of tissues can be characterized as a symphony of cellular activities often beginning with an acute inflammatory response followed by granulation tissue infiltration, recruitment, proliferation and differentiation of progenitor cells, matrix formation and organization, and eventual remodeling. The process occurs within the context of biologic and mechanical signals. While many scientists, engineers and clinicians working across numerous disciplines are dedicated to advancing the repair or regeneration of tissues and organs, they fall short in their ability to communicate, interpret, or integrate across the many core competencies that we believe are required to make substantial advances in regenerative medicine. These core competencies include: developmental biology, extracellular matrix structure and organization, bioregulatory signaling, tissue structure and function, preclinical models development, structural and computational modeling, clinical research design principles, and commercialization and regulatory parameters. This program will admit biologists, engineers and clinicians with training depth in one or more disciplines and augment their abilities by teaching them critical aspects of these core competencies through didactic and research intensive experiences. While this training program will expand to train in all organ or tissue systems in the future, its initial training will focus on musculoskeletal tissues.