Mitochondrial metabolism as a target for human metabolites of dietary anthocyanins

该研究预计将产生证据表明，特定的花青素代谢物对线粒体代谢具有有益的影响，并可能保护线粒体免于功能失调，例如当暴露于超最佳营养水平时（例如，在餐后阶段或在危险组中，例如那些被诊断为糖尿病前期或代谢综合征的患者）。这将是健康专业人士的兴趣，包括营养师/临床医生谁提供饮食建议的人谁是在发展代谢疾病的风险。这些发现也将对那些寻求开发和销售针对代谢功能障碍的产品的营养品公司感兴趣。在该项目中，对引起线粒体功能/能量代谢有益变化的特定花青素人体代谢物的鉴定可以支持未来的研发，以确定这些代谢物（可能是也可能不是花青素）的最佳来源，并随后开发新的营养产品。这些数据也可以用于开发益生元/益生菌/合生元，从长远来看，可以增加这些代谢物在肠道中的产量。如果这些体外观察得到适当设计和良好控制的人类饮食干预研究数据的支持，这项研究可以用于支持政策制定者饮食建议的变化。

The research is expected to generate evidence that specific anthocyanin metabolites have beneficial effects on mitochondrial metabolism and may protect mitochondria from becoming dysfunctional, for example when exposed to supra-optimal nutrient levels (e.g., during the post-prandial phase or in at-risk groups such as those diagnosed as pre-diabetic or metabolic syndrome). This will be of interest to health professionals including dieticians/clinicians who provide dietary advice to people who are at-risk of developing metabolic disease. The findings will also be of interest to nutraceutical companies who are seeking to develop and market products that target metabolic dysfunction. The identification of specific anthocyanin human metabolites that cause beneficial changes in mitochondrial function / energy metabolism in this project can underpin future R&D to identify the best sources of these metabolites (which may or may not be anthocyanins) and subsequently the development of new nutraceutical products. The data could also be used to develop pre-/pro-/syn-biotics that can increase production of these metabolites in the gut in the longer term this research could be used to underpin changes in dietary advice from policy makers if these invitro observations were backed up by data from properly designed and well controlled human dietary intervention studies.