Causes and consequence of short tandem repeat instability

对基因组的忠实复制对地球上的所有生命都是必不可少的。除了DNA复制，基因组还必须转录。然而，特定的DNA序列在任何时候都只能进行复制或转录。因此，转录和复制过程之间经常存在冲突，有可能导致基因组不稳定。细胞有有效的途径来防止转录-复制冲突。然而，这些途径还没有被很好地理解。我们最近开发了一种新的基因组技术，可以检测转录-复制冲突-这将使我们能够发现细胞保护基因组的途径。

Faithful copying of the genome is essential for all life on earth. In addition to DNA replication, the genome must also be transcribed. However, a specific DNA sequence can only be engaged in either replication or transcription at any one time. Therefore, there are frequently conflicts between the processes of transcription and replication that have the potential to result in genome instability. Cells have efficient pathways to prevent transcription-replication conflicts. However, these pathways are not well understood. We have recently developed a novel genomic technology that can detect transcription-replication conflicts - this will allow us to discover pathways that the celluses to protect the genome.