Causes and consequence of short tandem repeat instability

短串联重复序列不稳定性的原因和后果

• 批准号: 2869560
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2869560
• 关键词: Causes; consequence; short; tandem; repeat

Faithful copying of the genome is essential for all life on earth. In addition to DNA replication, the genome must also be transcribed. However, a specific DNA sequence can only be engaged in either replication or transcription at any one time. Therefore, there are frequently conflicts between the processes of transcription and replication that have the potential to result in genome instability. Cells have efficient pathways to prevent transcription-replication conflicts. However, these pathways are not well understood. We have recently developed a novel genomic technology that can detect transcription-replication conflicts - this will allow us to discover pathways that the celluses to protect the genome.

基因组的忠实复制对地球上的所有生命都至关重要。除了DNA复制，基因组也必须转录。然而，特定的DNA序列在任何一个时间只能参与复制或转录。因此，在转录和复制过程之间经常存在冲突，这有可能导致基因组不稳定。细胞有有效的途径来防止转录-复制冲突。然而，这些途径并没有得到很好的理解。我们最近开发了一种新的基因组技术，可以检测转录-复制冲突-这将使我们能够发现细胞保护基因组的途径。