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Gene Regulation in Memory Circuits as a Consequence of Polysubstance Use

Gene Regulation in Memory Circuits as a Consequence of Polysubstance Use
多物质使用导致的记忆电路基因调控
批准号:
10739399
负责人:
Karla R. Kaun
金额:
$51.29万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-08-01 至 2028-06-30

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中文摘要
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英文摘要
PROJECT SUMMARY: Methamphetamine is a highly addictive drug that has major effects on the brain’s learning and memory systems. Methamphetamine use is commonly predicted by high use of legal psychostimulants such nicotine or alcohol, but the mechanisms underlying sequential use of alcohol, nicotine and methamphetamine are not well understood. Both nicotine and alcohol alter the function of brain circuits required for adaptive decisions, but the cellular and molecular mechanisms through which this occurs largely remain a mystery. Identifying the gene regulatory networks within select circuits in high alcohol or high nicotine seeking animals and deciphering how methamphetamine alters these networks is necessary to decode the fundamental molecular underpinnings through which methamphetamine influences maladaptive choice. However, the diversity of circuits and cells involved in these responses has confounded our ability to identify key molecular pathways. Our goal is to use a genes-circuits-behavior approach in Drosophila melanogaster to provide an innovative and holistic understanding of the core fundamental principles through which sequential use of psychostimulants alter the molecular landscape and neural dynamics of memory circuits to alter behavioral decisions. Transcriptional regulation within memory circuits is a fundamental process through which psychostimulants drive maladaptive changes in the brain function. This work provides the causal gene regulatory mechanisms through which high preference for alcohol or nicotine affects methamphetamine response in memory circuits. This has major implications for how co-use of psychostimulants alters the molecular landscape that drives drug-seeking behavior.
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Whole-brain mapping of opiate-sensitive circuits in Drosophila
  • 批准号:
    9765603
  • 项目类别:
  • 资助金额:
    $20.31万
  • 财政年份:
    2019
  • 负责人:
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  • 依托单位:
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    9323532
  • 项目类别:
  • 资助金额:
    $29.66万
  • 财政年份:
    2017
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Notch-dependent microcircuit regulation of alcohol reward memory
  • 批准号:
    9173692
  • 项目类别:
  • 资助金额:
    $35.6万
  • 财政年份:
    2016
  • 负责人:
    Karla R. Kaun
  • 依托单位:
Notch-dependent microcircuit regulation of alcohol reward memory
  • 批准号:
    9982157
  • 项目类别:
  • 资助金额:
    $35.4万
  • 财政年份:
    2016
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  • 依托单位:
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