SPATIAL ANALYSIS FOR EXPOSURE ASSESSMENT OF PESTICIDES

农药暴露评估的空间分析

• 批准号: 7171034
• 负责人: JANE HARVILL
• 金额: $ 2.69万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171034
• 关键词: clinical research; neurotoxicology; pesticide biological effect; pesticides

DESCRIPTION (provided by applicant): The Center for Environmental Health Sciences (CEHS) within the CVM-MSU submits an application to develop a COBRE with the overall scientific theme of environmental health, and a specific emphasis on the toxicological effects of pesticides. Our COBRE would be a multi-disciplinary research effort with two overarching goals: 1) to develop individual junior faculty expertise and credibility so that each is recognized as a successful, fully enfranchised member of the community of environmental health scientists with independent, competitive funding support from peer-reviewed mechanisms (primarily R01 grants); and 2) to develop a team of scientists who can compete for programmatic research support, such as a program project grant, for investigation of environmental health problems elicited by agricultural chemicals. Organizationally, an Administrative Core would coordinate overall activities of the COBRE, and be responsible for mentoring the junior scientists in their career development to increase their competitiveness, and for data management activities (data entry and statistical guidance). Four biomedical mechanistic research projects will be based on hypothesis-driven studies of the potential effects of pesticides on the mammalian nervous or endocrine systems at various stages of development (from early development through aging). The mechanisms of toxicity of pesticides will be investigated in animal models (both traditional laboratory rodents as well as new animal models). A Research Resources Core would provide infrastructure to these biomedical projects through animal resources; (Animal Sub-Core) and shared instrumentation (Imaging Sub-Core and Analytical Chemistry Sub-Core). In addition, an epidemiology and exposure assessment project would bring real world perspectives to the biochemical and physiological mechanisms under study. Renovation of laboratory space would occur. The Principal Investigators (PI) of the science projects are junior faculty who demonstrate distinct but complementary areas of expertise, all of whom can contribute individually and programmatically to answering critical questions in the assessment of the impact of pesticides on selected areas of human health. All are committed to developing new or expanded expertise in scientific questions or methodologies useful in the area of environmental health, and that fit the priority research areas of the National Institute of Environmental Health Sciences (NIEHS), for whose support we hope to ultimately compete.

描述（由申请人提供）：CVM-MSU中环境健康科学中心（CEHS）提交了一种申请，以开发具有环境健康的整体科学主题的毛病，并特别强调农药的毒理学作用。我们的鞋匠将是一个多学科的研究工作，具有两个总体目标：1）发展个别的初级教师专业知识和信誉，以便每个人都被公认为是一位成功，全面的环境健康科学家社区成​​员，并具有独立的，有竞争力的资金支持，来自同行评估机制（主要是R01 Grant）； 2）建立一个科学家团队，他们可以争夺程序化研究支持的科学家，例如计划项目赠款，以研究农业化学品引起的环境健康问题。在组织上，行政核心将协调鞋底的整体活动，并负责指导初级科学家的职业发展以提高其竞争力和数据管理活动（数据输入和统计指导）。四个生物医学机械研究项目将基于假设驱动的研究，该研究对各个发育阶段（从早期发育到衰老），农药对哺乳动物神经或内分泌系统的潜在影响。将在动物模型（传统的实验室啮齿动物和新动物模型）中研究农药毒性的机制。研究资源核心将通过动物资源为这些生物医学项目提供基础设施； （动物亚核）和共享仪器（成像子核和分析化学子核）。此外，流行病学和暴露评估项目将为正在研究的生化和生理机制带来现实世界的观点。实验室空间的翻新。科学项目的主要研究人员（PI）是初级教职员工，他们表现出独特但互补的专业知识领域，所有这些领域都可以在评估农药对某些人类健康领域的影响的评估时单独和编程地回答关键问题。所有人都致力于在科学问题或方法论中开发新的或扩展的专业知识，可用于环境健康领域，并适合美国国家环境健康科学研究所（NIEHS）的优先研究领域，我们希望他们最终能够竞争他们的支持。