IN VIVO AND IN VITRO EFFECTS OF THE PESTICIDE ATRAZINE ON BASAL GANGLIA FUNCTION

农药阿特拉津对基底节功能的体内外影响

• 批准号: 7171027
• 负责人: NIKOLAY M FILIPOV
• 金额: $ 12.69万
• 依托单位: MISSISSIPPI STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171027
• 关键词: clinical research; neurotoxicology; pesticide biological effect; pesticides

DESCRIPTION (provided by applicant): The Center for Environmental Health Sciences (CEHS) within the CVM-MSU submits an application to develop a COBRE with the overall scientific theme of environmental health, and a specific emphasis on the toxicological effects of pesticides. Our COBRE would be a multi-disciplinary research effort with two overarching goals: 1) to develop individual junior faculty expertise and credibility so that each is recognized as a successful, fully enfranchised member of the community of environmental health scientists with independent, competitive funding support from peer-reviewed mechanisms (primarily R01 grants); and 2) to develop a team of scientists who can compete for programmatic research support, such as a program project grant, for investigation of environmental health problems elicited by agricultural chemicals. Organizationally, an Administrative Core would coordinate overall activities of the COBRE, and be responsible for mentoring the junior scientists in their career development to increase their competitiveness, and for data management activities (data entry and statistical guidance). Four biomedical mechanistic research projects will be based on hypothesis-driven studies of the potential effects of pesticides on the mammalian nervous or endocrine systems at various stages of development (from early development through aging). The mechanisms of toxicity of pesticides will be investigated in animal models (both traditional laboratory rodents as well as new animal models). A Research Resources Core would provide infrastructure to these biomedical projects through animal resources; (Animal Sub-Core) and shared instrumentation (Imaging Sub-Core and Analytical Chemistry Sub-Core). In addition, an epidemiology and exposure assessment project would bring real world perspectives to the biochemical and physiological mechanisms under study. Renovation of laboratory space would occur. The Principal Investigators (PI) of the science projects are junior faculty who demonstrate distinct but complementary areas of expertise, all of whom can contribute individually and programmatically to answering critical questions in the assessment of the impact of pesticides on selected areas of human health. All are committed to developing new or expanded expertise in scientific questions or methodologies useful in the area of environmental health, and that fit the priority research areas of the National Institute of Environmental Health Sciences (NIEHS), for whose support we hope to ultimately compete.

描述（由申请人提供）：CVM-MSU内的环境健康科学中心（CEHS）提交了一份开发COBRE的申请，该COBRE具有环境健康的整体科学主题，并特别强调农药的毒理学效应。我们的COBRE将是一个多学科的研究工作，有两个首要目标：1）发展个人初级教师的专业知识和信誉，使每个人都被公认为环境健康科学家社区的成功，充分享有权利的成员，并获得同行评审机制的独立，竞争性资金支持（主要是R 01赠款）; 2）培养一个科学家团队，他们可以竞争计划研究支持，例如计划项目补助金，用于调查农业化学品引起的环境健康问题。在行政方面，一个行政核心将协调协调协调委员会的总体活动，并负责指导年轻科学家的职业发展，以提高他们的竞争力，并负责数据管理活动（数据输入和统计指导）。四个生物医学机制研究项目将以农药对处于不同发育阶段（从早期发育到衰老）的哺乳动物神经或内分泌系统的潜在影响的假设研究为基础。农药的毒性机制将在动物模型（传统的实验室啮齿动物以及新的动物模型）中进行研究。研究资源核心将通过动物资源（动物子核心）和共享仪器（成像子核心和分析化学子核心）为这些生物医学项目提供基础设施。此外，一个流行病学和接触评估项目将为正在研究的生物化学和生理机制带来真实的世界视角。将对实验室空间进行改造。科学项目的主要研究者（PI）是初级教师，他们表现出独特但互补的专业领域，所有这些人都可以单独和有计划地回答评估农药对人类健康选定领域影响的关键问题。所有人都致力于开发新的或扩大的专业知识，在环境健康领域有用的科学问题或方法，并适合国家环境健康科学研究所（NIEHS）的优先研究领域，我们希望最终竞争其支持。