COBRE: RIH: CORE C: MOLECULAR PATHOLOGY, TRANSGENIC RAT, ANIMAL MODEL OF CANCER

COBRE：RIH：核心 C：分子病理学、转基因大鼠、癌症动物模型

• 批准号: 7171098
• 负责人: RONALD DELELLIS
• 金额: $ 15.48万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171098
• 关键词: clinical research; health science research potential; neoplasm /cancer

DESCRIPTION (provided by applicant): The mission of the Center for Cancer Research Development is to coalesce and foster outstanding, interactive, laboratory-based cancer research centered on the Molecular and Cellular Pathogenesis of Cancer. To this end, three program projects, each with two subprojects will be initiated in year one along with four pilot projects, the latter supported by funds from Rhode Island Hospital/Academic Medical Center (RIH/AMC). The goal will be to develop program projects in four different but related themes, into interactive research groups composed of at least 3 junior investigators supported by peer reviewed grants. This will be accomplished by establishing and perpetuating an intellectually dynamic training environment in which junior investigators will create and disseminate new knowledge and clinical applications and with the guidance of senior faculty mentors, build nationally competitive, independent, but interactive research programs. The investigators will utilize common model systems and state-of-the-art core facilities in administration, career development, proteomics and molecular pathology to 1) discover mechanisms leading to neoplasia and 2) develop clinical applications resulting from this knowledge. The six subprojects, mentored by a team of seven senior faculty including the PI and Co-PI, target programmatic themes in gastrointestinal cancer, developmental proteins and intracellular signaling pathways. A fourth theme in viral mechanisms of carcinogenesis is represented by pilot projects funded by the institution. The proposal represents a strategic partnership in which RIH/AMC will commit significant resources to supplement those requested in this application to build cohesive strength in basic cancer research that complements existing strengths in clinical cancer treatment, outreach, and prevention. The long-term goal of this support is to achieve NCI designation as a Comprehensive Cancer Center. Guidance for the Center will be provided by teams of Internal and External Advisors and Consultants including a Translational Research Group together with a carefully considered plan of training, evaluation and succession. The end result will be a Cancer Research Center of investigators with significant programmatic strengths and translational impact.

描述（由申请人提供）：癌症研究发展中心的使命是整合和促进以癌症分子和细胞发病机制为中心的杰出的、互动的、基于实验室的癌症研究。为此目的，将在第一年启动三个方案项目，每个项目有两个子项目，以及四个试点项目，后者由罗德岛医院/学术医疗中心（RIH/AMC）提供资金支持。目标是将四个不同但相关主题的项目发展成由至少3名初级研究人员组成的互动研究小组，并获得同行评审的资助。