TRANSEPITHELIAL ION TRANSPORT & ITS REGULATION

描述（由申请人提供）：一个COBRE奖兽医学院（CVM）在KU将提供必要的资源，以提升初级基础研究人员和临床科学家在这个和其他堪萨斯机构的研究计划，成为成功获得独立的NIH资金。KU CVM和KU和KUMC合作部门的七个初级教师和导师团队已被确定为有资格启动该计划。全州范围内的竞争将确定更多的初级教师和他们的导师在以后几年的奖项。所有已确定的计划都以上皮细胞生理学或病理生理学为中心，并为转化研究提供了坚实的基础。为了提高项目的成功率，将建立3个核心设施：1）最先进的共聚焦显微镜设施，2）基因阵列分析站和3）上皮电生理设施。所有的努力和支出都将以尽快将初级教师提升到独立的NIH资助的研究者的水平为最终目标。为此，该COBRE的项目负责人沿着与其他导师和咨询委员会成员将创建并参与一个结构化的跨学科互动计划，包括视频会议研讨会和密集的个人指导。导师和初级教师对他们的责任领域的问责制将通过行政程序得到保证。拟议计划的成功取决于项目的科学价值、个别研究人员的研究实力、初级和高级教师对指导计划目标的热情承诺以及对CVM比较生物医学研究的加强。KU的CVM管理部门高度支持其研究和临床教师，但这个COBRE奖将提供财政手段和结构化的计划，以充分实现其有才华的青年教师的“承诺”。

DESCRIPTION (provided by applicant): A COBRE award to the College of Veterinary Medicine (CVM) at KU will provide the resources necessary to elevate the research programs of junior basic researchers and clinician-scientists at this and other Kansas institutions to become successful at obtaining independent NIH funding. Seven teams of junior faculty members and mentors in the KU CVM and collaborating departments at KU and at KUMC have been identified as qualified to initiate this program. Statewide competition will identify additional junior faculty and their mentors in the later years of the award. All of the identified programs center on epithelial cell physiology or pathophysiology and provide a strong foundation for translational research. To enhance programmatic success 3 core facilities will be established: 1) a state-of-the-art confocal microscope facility, 2) gene array analysis station and 3) an epithelial electrophysiology facility. All efforts and expenditures will be guided by the ultimate goal of moving the junior faculty to the level of independent NIH-funded investigator as rapidly as possible. To this end, the project leader of this COBRE along with the other mentors and advisory committee members will create and participate in a structured program of interdisciplinary interactions in video-conferenced seminars and intensive individual l guidance. Accountability of mentors and junior faculty for their areas of responsibility will be assured by the administrative processes. The success of the proposed program is predicted by the scientific merit of the projects, the research strength of the individual investigators, the enthusiastic commitment of junior and senior faculty to the goals of the mentoring program and enhancement of comparative biomedical research at the CVM The administration at the CVM at KU is highly supportive of its research and clinical faculty, but this COBRE award will provide the financial means and the structured program to realize fully the "promise" of its talented junior faculty.