NSAIDS, POLYAMINE-DEPLETION & DEPOLARIZED MEMBRANE POTENTIAL

非甾体抗炎药、多胺消耗

• 批准号: 7171090
• 负责人: JAMES D LILLICH
• 金额: $ 21.1万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171090
• 关键词: cell biology; clinical research; epithelium

DESCRIPTION (provided by applicant): A COBRE award to the College of Veterinary Medicine (CVM) at KU will provide the resources necessary to elevate the research programs of junior basic researchers and clinician-scientists at this and other Kansas institutions to become successful at obtaining independent NIH funding. Seven teams of junior faculty members and mentors in the KU CVM and collaborating departments at KU and at KUMC have been identified as qualified to initiate this program. Statewide competition will identify additional junior faculty and their mentors in the later years of the award. All of the identified programs center on epithelial cell physiology or pathophysiology and provide a strong foundation for translational research. To enhance programmatic success 3 core facilities will be established: 1) a state-of-the-art confocal microscope facility, 2) gene array analysis station and 3) an epithelial electrophysiology facility. All efforts and expenditures will be guided by the ultimate goal of moving the junior faculty to the level of independent NIH-funded investigator as rapidly as possible. To this end, the project leader of this COBRE along with the other mentors and advisory committee members will create and participate in a structured program of interdisciplinary interactions in video-conferenced seminars and intensive individual l guidance. Accountability of mentors and junior faculty for their areas of responsibility will be assured by the administrative processes. The success of the proposed program is predicted by the scientific merit of the projects, the research strength of the individual investigators, the enthusiastic commitment of junior and senior faculty to the goals of the mentoring program and enhancement of comparative biomedical research at the CVM The administration at the CVM at KU is highly supportive of its research and clinical faculty, but this COBRE award will provide the financial means and the structured program to realize fully the "promise" of its talented junior faculty.

描述（由申请人提供）：向 KU 兽医学院 (CVM) 颁发的 COBRE 奖将提供必要的资源，以提升该机构和堪萨斯州其他机构的初级基础研究人员和临床科学家的研究项目，以成功获得独立的 NIH 资助。 KU CVM 以及 KU 和 KUMC 合作部门的七支初级教师和导师团队已被确定有资格启动该计划。全州范围内的竞赛将在该奖项的后期确定更多的初级教师及其导师。所有已确定的项目都以上皮细胞生理学或病理生理学为中心，并为转化研究提供了坚实的基础。为了提高计划的成功率，将建立 3 个核心设施：1）最先进的共聚焦显微镜设施，2）基因阵列分析站和 3）上皮电生理学设施。所有的努力和支出都将以尽快将初级教师提升为 NIH 资助的独立研究者的水平为指导。为此，COBRE 的项目负责人以及其他导师和咨询委员会成员将创建并参与视频会议研讨会和强化个人指导中跨学科互动的结构化计划。行政流程将确保导师和初级教师对其职责范围的问责。拟议项目的成功取决于项目的科学价值、个别研究人员的研究实力、初级和高级教师对指导计划目标的热情承诺以及 CVM 比较生物医学研究的加强。KU CVM 的管理部门高度支持其研究和临床教师，但该 COBRE 奖项将提供财务手段和结构化计划，以充分实现其“承诺” 才华横溢的初级教师。