Nebraska Redox Biology Center

描述(由申请人提供)：这个想法提案提出了一个详细的计划，在内布拉斯加州为氧化还原生物学创建一个多学科的生物医学研究卓越中心(COBRE)。该中心将把该州两个领先的研究活跃机构--联合国林肯机构和UNMC的科学家联系起来，共同努力揭开氧化还原生物学中的基本问题，这些问题影响到一些疾病的发病机制，包括一些癌症、关节炎和心血管疾病，以及衰老等自然现象的进展。拟议中心的目标是(I)通过创建一个基础设施来提高该州的生物医学研究能力，该基础设施将从战略上将两个机构在氧化还原生物学方面的强大研究项目联系起来，以及(Ii)指导初级教员干部与NIH的独立资助成功。 这些目标将通过为初级研究人员提供丰富和严格的指导环境，通过加强核心设施，通过促进两个机构的科学家之间的合作，并通过增加五名在氧化还原生物学领域有研究兴趣的教职员工来实现，以确保维持一个全国知名和国际公认的中心所需的足够数量的科学家。该中心组织的一个关键设计特点是，由一名具有相似研究兴趣和NIH成功资助记录的知名调查员指导五名发展中的教职员工。随着这些项目负责人向资金独立过渡，他们的项目将被新招聘的教职员工领导的项目所取代。一位具有提供有效领导所需的远见、科学知识和行政经验的主任将主要负责指导该中心。她将接受指导委员会成员的咨询，指导委员会由内布拉斯加州各机构的五名知名科学家组成，并由外部咨询委员会(EAC)指导，该委员会由八名杰出科学家组成，其中五名是国家科学院的成员，所有人都同意担任这一职务。 该中心的创建所产生的协同环境将丰富该州的研究文化，将活跃其生物医学科学家社区，并将提高关键核心设施的质量和产品。

DESCRIPTION (provided by applicant): This IDeA proposal presents a detailed plan to create a rnultidisciplinary Center for Biomedical Research Excellence (COBRE) in Nebraska for Redox Biology. The Center will link scientists at the two leading research-active institutions in the state - the UN-Lincoln and the UNMC - in a collaborative pursuit to unravel fundamental problems in redox biology that impact the pathogenesis of a number of diseases including some cancers, arthritis and cardiovascular diseases and the progression of natural phenomena such as aging. The objectives of the proposed Center are (i) to enhance biomedical research capacity in the state by creating an infrastructure that will strategically link strong research programs in redox biology at the two institutions and (ii) to mentor a cadre of junior faculty to independent funding success at NIH. These objectives will be met by providing a rich and rigorous mentoring environment for junior investigators, by bolstering core facilities, by fostering collaborations among scientists at both institutions and by recruiting five additional faculty members with research interests in the area of redox biology to ensure the critical mass of scientists necessary to sustain a nationally visible and internationally recognized Center. A key design feature for the organization of the Center is the mentoring of each of the five developing faculty members by an established investigator with similar research interests and a successful track record of funding at NIH. As these project leaders transition to funding independence, their projects will be replaced by ones led by the newly recruited faculty members. A Director with the vision, scientific expertise and administrative experience necessary to provide effective leadership will be primarily responsible for steering the Center. She will be counseled by members of the Mentoring Council, comprising five established scientists at the Nebraska institutions, and guided by an External Advisory Council (EAC) comprising eight outstanding scientists, five of whom are members of the National Academy of Sciences, and all of whom have agreed to serve in this capacity. The synergistic environment resulting from the creation of the Center will enrich the culture of research in the state, will enliven its community of biomedical scientists and will elevate the quality and offerings of key core facilities.