Reverse Engineering Cortical Circuitry

逆向工程皮质电路

• 批准号: 7214182
• 负责人: William W Lytton
• 金额: $ 20.13万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214182
• 关键词: Address; Algorithms; Behavior; Biological; Biological Neural Networks; Biology; Brain; Cell model; Cells; Class; Classification; Collaborations; Complement; Complex; Computer Simulation; Data; Depth; Distal; Electric Stimulation; Electrodes; Encapsulated; Engineering; Epilepsy; Epileptogenesis; Facility Construction Funding Category; Fiber; Fire - disasters; Glutamate Receptor; Glutamates; Grouping; Hippocampal Formation; Hippocampus (Brain); Hybrids; Interneurons; Investigation; Localized; Location; Maps; Measures; Methods; Modeling; Morphology; Neocortex; Neural Network Simulation; Neurons; Numbers; Output; Pattern; Physiological; Physiology; Property; Pyramidal Cells; Range; Rate; Rattus; Relative (related person); Research; Seizures; Site; Slice; Software Tools; Speed; Staging; Structure; Synapses; Technology; Testing; Time; Trees; Variant; Work; base; computer network; extracellular; gamma-Aminobutyric Acid; hippocampal pyramidal neuron; improved; insight; network models; neuronal cell body; pressure; research study; response; simulation; size; software development; transmission process; voltage

DESCRIPTION (provided by applicant): The subiculum is a crossroads of hippocampal and parahippocampal projections, and the major output structure of the region. The subiculum is a region of intermediate complexity between CA3, a region with a single layer of interconnected pyramidal neurons, and the 6-layered parahippocampal and neocortices, regions with multiple principal cells connected via intralaminar and interlaminar circuits. Physiological investigation and modeling of CA3 has provided many insights into basic epileptogenesis. The greater complexity and location of subiculum makes it a logical next structure for study of additional mechanisms of seizure origin and spread. We propose to evaluate connectivity and activity spread in subiculum by combining anatomical and physiological methods with computer modeling. We will focus on network dynamics, using existing results to define voltage-sensitive and synaptic channels for the cell models. The research will proceed via the following specific aims: AIM 1: Measure subthreshold and suprathreshold properties of pyramidal and interneurons of subiculum and relate these to firing patterns and dendritic morphology. AIM 2: Develop combined and hybrid neural network software tools and fitting algorithms to match models to physiology. AIM 3: Define input/output relations for subicular pyramidal cells to excitatory and inhibitory connections. AIM 4: Explore spread of activity with multi-electrode recordings and match patterns of spread to the computer network model. Our research will allow us to begin to define and classify patterns of activity initiation, filtering, sustention and boosting in cortical circuits. This will set the stage for use of the subiculum slice and subiculum computer model as an epilepsy model.

描述（由申请人提供）：耻骨下是海马和海马旁投射的十字路口，是该区域的主要输出结构。枕下是介于CA3和6层海马旁和新皮质之间的一个中等复杂的区域，CA3是一个由单层相互连接的锥体神经元组成的区域，海马旁和新皮质是一个由多个主要细胞通过层内和层间回路连接的区域。CA3的生理研究和建模为基本的癫痫发生提供了许多见解。更大的复杂性和坐骨下的位置使其成为下一个研究癫痫发作起源和扩散机制的逻辑结构。我们建议将解剖学和生理学方法与计算机建模相结合来评估耻骨下的连通性和活动扩散。我们将关注网络动力学，利用现有的结果来定义细胞模型的电压敏感通道和突触通道。目的1：测量丘下锥体和中间神经元的阈下和阈上特性，并将其与放电模式和树突形态联系起来。目标2：开发组合和混合神经网络软件工具和拟合算法，将模型与生理学相匹配。目的3：定义丘下锥体细胞对兴奋性和抑制性连接的输入/输出关系。目标4：通过多电极记录探索活动的传播，并将传播模式与计算机网络模型相匹配。我们的研究将使我们能够开始定义和分类皮层回路中的活动启动、过滤、维持和增强模式。这将为使用枕骨下切片和枕骨下计算机模型作为癫痫模型奠定基础。

项目成果

Computer modelling of epilepsy.

• DOI: 10.1038/nrn2416
• 发表时间: 2008-08
• 期刊: NATURE REVIEWS NEUROSCIENCE
• 影响因子: 34.7
• 作者: Lytton, William W.

Unmasking the CA1 ensemble place code by exposures to small and large environments: more place cells and multiple, irregularly arranged, and expanded place fields in the larger space.

• DOI: 10.1523/jneurosci.2862-08.2008
• 发表时间: 2008-10-29
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
• 通讯作者: Ludvig N

The virtual slice setup.

虚拟切片设置。

• DOI: 10.1016/j.jneumeth.2008.03.005
• 发表时间: 2008
• 期刊: Journal of neuroscience methods
• 影响因子: 3
• 作者: Lytton,WilliamW;Neymotin,SamuelA;Hines,MichaelL
• 通讯作者: Hines,MichaelL

Hybrid neural networks--combining abstract and realistic neural units.

混合神经网络——结合了抽象和现实的神经单元。

• DOI: 10.1109/iembs.2004.1404116
• 发表时间: 2004
• 期刊: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
• 作者: Lytton,WilliamW;Hines,Michael
• 通讯作者: Hines,Michael

Broadening of activity with flow across neural structures.

随着跨神经结构的流动扩大活动。

• DOI: 10.1068/p5871
• 发表时间: 2008
• 期刊: Perception
• 影响因子: 1.7
• 作者: Lytton,WilliamW;Orman,Rena;Stewart,Mark
• 通讯作者: Stewart,Mark